应用BED-CEIA方法估算江苏省男男性行为人群艾滋病病毒感染的新发感染率  

Estimation of HIV-1 incidence of MSM in Jiangsu Province with BED-CEIA assay

作　　者：胡海洋[1] 沈圣[2] 还锡萍[1] 闫红静[1] 肖瑶[2] 蒋岩[2] 

机构地区：[1]江苏省疾病预防控制中心性病与艾滋病防制所,江苏南京210009 [2]中国疾病预防控制中心,性病艾滋病预防控制中心,国家艾滋病参比实验室,北京100050

出　　处：《南京医科大学学报（自然科学版）》2010年第4期467-471,共5页Journal of Nanjing Medical University(Natural Sciences)

基　　金：江苏省社会发展计划资助项目(BE2009685)

摘　　要：目的:了解江苏省男男性行为人群(MSM)艾滋病病毒(HIV)的感染状况,估算HIV在该人群中的新发感染率。方法:对2008年国家男男性行为人群艾滋病综合防治试点工作的710份样本,进行HIV-1初筛、复检及确证试验,检出的HIV-1阳性样本,再应用BEDHIV-1IgG捕获酶免疫法(BED-CEIA)检出其中的新发感染样本,进而估算该人群的HIV-1新发感染率。结果:710份样本共检出HIV-1阳性样本40份,HIV-1感染率为5.63%;40份HIV-1阳性样本中的23份被判定为新发感染,感染者中新发感染的比例高达57.5%;校正后的HIV-1新发感染率为7.54%(95%CI:4.46%～10.62%)。结论:HIV-1在江苏省MSM人群中的流行已经处于较高水平且新发感染状况不容乐观,必须加大防控力度。Objective：To understand HIV infection of men who have sex with men（MSMs） in Jangsu Province,and estimate the annual HIV incidence of MSMs. Methods：710 samples from national pilot work of HIV/AIDS comprehensive prevention and care among MSMs in 2008 were tested to find HIV-1 seropositive samples.BED HIV-1 IgG capture enzyme immunoassay（BED-CEIA） was used to find recent HIV-1 infections in HIV-1 seropositive samples,and the annual HIV-1 incidence of MSMs was estimated. Results：40 samples were HIV-1 seropositive and the HIV-1 infection incidence was 5.63%. 23 samples were confimrcl to be recently infected,and the recent infection rate was 57.5%. The corrected annual HIV-1 incidence was 7.54%（95% CI：4.46%-10.62%）among MSMs. Conclusion：The HIV-1 infectin in MSMs in Jiangsu Province has entered a period of rapid growth,powerful prevention and control efforts must be performed.

关 键 词：艾滋病病毒 BED—CEIA 新发感染率 男男性行为人群 

分 类 号：R512.91[医药卫生—内科学]