儿童急性淋巴细胞白血病危险因素的病例对照分析  

The risk factors of childhood acute lymphoblastic leukemia a case-control analysis

作　　者：方拥军[1] 仝娜[2] 肖继好 王美林[2] 张正东[2] 戎留成[1] 徐红艳[1] 李捷[4] 王亚明[5] 郭锡熔[6] 

机构地区：[1]南京医科大学附属南京儿童医院血渍肿瘤科,江苏南京210008 [2]南京医科大学公共卫生学院,江苏南京210029 [3]苏州市平江医院儿科,江苏苏州215031 [4]苏州大学附属儿童医院血液肿瘤科,江苏苏州215002 [5]蚌埠医学院附属医院儿科,安徽蚌埠233001 [6]南京医科大学儿科研究所,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2010年第4期522-524,545,共4页Journal of Nanjing Medical University(Natural Sciences)

基　　金：南京市卫生科技发展基金(ZKM05039)

摘　　要：目的:探索儿童急性淋巴细胞性白血病(ALL)发生的危险因素,为该地区儿童ALL的防治提供依据。方法:采用病例对照的流行病学研究方法,对233例ALL患者及380例健康对照进行问卷调查,资料处理采用EPIDATA3.02录入,SPSS13.0统计分析,通过Logistic回归模型进行单因素和多因素分析,计算比值比(OR),估计各危险因素与儿童ALL的关联强度。结果:所调查的因素中共筛选出8项与ALL发病有关的危险因素,其中5项(是否与父母共同居住、是否早产、儿童杀虫剂接触史、儿童父母亲是否吸烟、家庭是否装修)在多因素回归仍有显著意义。结论:儿童急性淋巴细胞性白血病的发生是多种因素共同作用的结果,在当地针对上述因素进行预防可降低儿童ALL发生的危险性。Objective：To explore the risk factors of childhood acute lymphoblastic leukemia（ALL） in Chinese. Methods：A case-control study including 233 cases and 380 controls and univariate and multivariate logistic regression were employed to evaluate the association of the factors in childhood ALL. Analysis was carried out with SPSS13.0 software. Results：In the univariate logistic analysis,subjects living without parents,with immature labor,un-spontaneous delivery,biocide exposure,paternal alcohol exposure,actino-exposure,houses painting and chemical exposure were the statistically significant risk factors of childhood ALL. Multivariate logistic analysis also revealed that living without parents,with immature labor,biocide exposure,paternal alcohol exposure,and houses painting were the risk factors. Conclusion：Living without parents,with immature labor,biocide exposure,paternal alcohol exposure,and houses painting are associated with the childhood ALL.

关 键 词：儿童ALL 危险因素 病例对照分析 

分 类 号：R725.5[医药卫生—儿科]