盘内注射臭氧治疗腰椎间盘突出症的剂量研究  

Study on the ozone dose used for the injection therapy of lumbar intervertebral disc protrusion

作　　者：任峰奇[1] 史步进 赵金平 王义清[1] 

机构地区：[1]陕西省西安市中心医院介入科,710003 [2]陕西省蒲城县创伤医院CT室

出　　处：《介入放射学杂志》2010年第3期233-235,共3页Journal of Interventional Radiology

摘　　要：目的确定臭氧治疗腰椎间盘突出症(LDH)盘内注射的合适剂量。方法将240例LDH患者用随机分组法分为4组,通过CT引导下穿刺突出椎间盘并分别注射4种剂量(分别为10、20、30和40ml)的医用臭氧(浓度为50μg/ml)。注射后即刻行CT扫描,随访观察6～12个月,对髓核汽化消融的程度、疗效及不良反应进行对比研究。结果10ml组疗效较其他组差,与其他3组比较差异有统计学意义(P<0.05),其余3组疗效之间差异无统计学意义(P>0.05),而随着剂量的增加并发症明显增加。结论臭氧治疗腰椎间盘突出症,盘内注射的合适剂量为20ml。Objective To determine the optimal injection dose of ozone for the treatment of lumbar intervertebral disc protrusion.Methods A total of 240 patients with lumbar intervertebral disc protrusion were randomly and equally divided into four groups,with 60 patients in each group.Under CT guidance intervertebral injection of ozone was performed.The injection dose of ozone（50 ug/ml）used for patients in group A,B,C and D was 10 ml,20 ml,30 ml and 40 ml respectively.Immediately after the procedure CT scanning was made to check the result.A follow-up lasting 6-12 months was carried out.Clinical observation,including the ablation degree of the nucleus pulposus,the therapeutic results and the adverse reactions,was conducted.The results were statistically analyzed and compared among the four groups. Results A significant difference in the therapeutic effect existed between group A（10 ml）and other three groups（P〈0.05）,while no significant difference in the therapeutic effect existed among group B（20 ml）, group C（30 ml）and group D（40 ml）,with P〈0.05.The occurrence of complications was increasing with the injection dose used.Conclusion The optimal injection dose of ozone for the treatment of lumbar intervertebral disc protrusion is 20 ml.

关 键 词：医用臭氧 腰椎间盘突出症 剂量 

分 类 号：R681.53[医药卫生—骨科学]