IL-13和TNF-α在肺炎支原体肺炎儿童血清中的表达及意义  

Serum levels of IL-13 and TNF-α in children with Mycoplasma pneumoniae pneumonia

作　　者：郦银芳[1] 于莹[1] 陆志芳[1] 

机构地区：[1]南京医科大学附属南京第一医院儿科,江苏南京210006

出　　处：《中国当代儿科杂志》2010年第4期275-277,共3页Chinese Journal of Contemporary Pediatrics

摘　　要：目的观察白细胞介素13(interleukin-13,IL-13)和肿瘤坏死因子α(tumor necrosis factor alpha,TNF-α)在小儿肺炎支原体肺炎中的变化。方法酶联免疫方法检测40例肺炎支原体肺炎伴喘息患儿、40例肺炎支原体肺炎不伴喘息患儿、其他病原菌感染肺炎40例(普通肺炎组)及40例正常对照组儿童的血清IL-13和TNF-α的浓度。结果肺炎支原体肺炎患儿血清IL-13、TNF-α的水平高于正常对照组及普通肺炎组;肺炎支原体肺炎伴喘息患者的IL-13、TNF-α的水平分别为214.6±67.2ng/L,0.55±0.13ng/L,高于不伴喘息者(189.6±52.1ng/L,0.42±0.16ng/mL),差异均有显著性(P<0.01)。结论IL-13、TNF-α浓度增高可能在小儿肺炎支原体肺炎导致喘息样发作中起重要作用。Objective To examine serum levels of interleukin-13 （IL-13） and tumor necrosis factor alpha （TNF-α） in children with Mycoplasma pneumoniae （MP） pneumonia.Methods Eighty children with MP pneumonia complicated by wheezing or without （n=40 each）,40 children with pneumonia from non-MP infection and 40 healthy children were enrolled.Serum levels of IL-13 and TNF-α were measured using ELISA.Results The serum levels of IL-13 and TNF-α in the MP pneumonia group were significantly higher than those in non-MP pneumonia group and the healthy control group （P0.01）.The children with MP pneumonia complicated by wheezing had increased serum levels of IL-13 （214.6±67.2 ng/L vs 189.6±52.1 ng/L;P0.01） and TNF-α （0.55±0.13 ng/mL vs 0.42±0.16 ng/mL;P0.01）compared with those without wheezing.Conclusions The increase in serum levels of IL-13 and TNF-α may play important roles in the pathogenesis of MP pneumonia and wheezing attack in children.

关 键 词：肺炎支原体肺炎 喘息 白细胞介素13 肿瘤坏死因子Α 儿童 

分 类 号：R725.6[医药卫生—儿科]