阿托伐他汀、阿司匹林对高血压患者血小板微粒CD62p、CD40L的影响  

Effect of atorvastatin and aspirin on the platelet membrane protein microparticles CD62p and CD40L in patients with hypertension

作　　者：赵燕[1] 杨明[1] 崔建英[1] 李颖[1] 孙一光[1] 朱小刚[1] 王平[1] 马杰[1] 

机构地区：[1]首都医科大学附属复兴医院心内科,北京100038

出　　处：《临床心血管病杂志》2010年第3期193-195,共3页Journal of Clinical Cardiology

摘　　要：目的:探讨血小板膜糖蛋白微粒CD62p、CD40L与高血压的关系,以及他汀类、抗血小板药物对其影响。方法:采用流式细胞术(FCM)及单克隆抗体标记法,检测70例高血压患者(高血压组)、20例健康者(对照组)的血液标本,以20μmol/LADP为激活剂激活血小板,35例服用阿司匹林100mgQD,35例同时服用阿司匹林100mgQD和阿托伐他汀20mgQN,检测高血压患者血小板膜糖蛋白微粒CD62p、CD40L水平及药物对其作用。结果:高血压组CD62p、CD40L的百分率(85.3%±11.8%、69.2%±8.6%)比对照组(52.8%±7.6%、35.2%±5.4%)高(P<0.01),服用阿司匹林组CD62p、CD40L的百分率降至(64.2%±9.3%、47.7%±7.4%)与服药前有显著性差异(P<0.05),同时服用阿司匹林和阿托伐他汀组CD62p、CD40L的百分率降至(49.7%±9.8%、36.2%±5.1%)与服药前及只服用阿司匹林相比均差异有统计学意义(P<0.01)。结论:高血压与血小板膜糖蛋白微粒CD62p、CD40L的表达存在一定的联系,阿司匹林、阿托伐他汀可降低血小板微粒CD62p、CD40L水平。Objective：To investigate the platelet membrane glycoprotein particles CD62p,CD40L and the relationship in high blood pressure,as well as statins,anti-platelet drugs on it.Method：We used the flow cytometry（FCM）and monoclonal antibody labeling to detect 70 cases of hypertension（hypertension group）and 20 healthy control＇s（control group）blood samples activated by 20 μmol/l L ADP.Then we detected the membrane protein microparticlesCD62p and CD40L in 35 patients with aspirin 100 mg QD or 35 cases of aspirin plus atorvastatin 20mg QN.Result：The contents of CD62p and CD40L in hypertension group（[85.3±11.8]%,[69.2±8.6]%）were significantly higher than control group（[52.8±7.6]%,[35.2±5.4]%）（P0.01）.Treated with aspirin,the patients showed a decline of CD62p and CD40L（[64.2±9.3]%,[47.7±7.4]%）（P0.05）.Treated with aspirin and atorvastatin,the patients showed a significant decline of CD62p and CD40L（[49.7±9.8]%,[36.2±5.1]%）（P0.01）.Conclusion：There is a certain relationship between the membrane protein of platelet microparticles and hypertension.The contents of CD62p and CD40L decrease in the hypertention patients after being treated with aspirin and atorvastatin.

关 键 词：高血压 血小板膜糖蛋白 CD62P CD40L 

分 类 号：R544.1[医药卫生—心血管疾病]