慢性乙型肝炎患者血细胞计数与肝脏组织学的关系  

The relation between peripheral blood cell count and liver histology in patients with chronic hepatitis B

作　　者：徐桂娟[1] 杨晴[1] 陈阳[1] 

机构地区：[1]沈阳市第六人民医院,辽宁沈阳110006

出　　处：《临床肝胆病杂志》2010年第2期182-184,共3页Journal of Clinical Hepatology

摘　　要：目的研究乙型病毒性肝炎患者血细胞计数与肝组织炎症和纤维化的关系。方法398例慢性乙型病毒性肝炎患者按肝组织纤维化分期分为S0-S4五组,按肝组织炎症分级分为G1-G4四组;常规方法检测外周血红细胞(RBC)、白细胞(WBC)和血小板计数(PLT),并进行相关统计学处理。结果RBC、WBC、和PLT与肝组织纤维化和炎症程度均呈负相关(P<0.05),PLT相关性最好;PLT与肝纤维化分期和炎症分级的相关系数分别是0.743、0.688。PLT分别在S0-S4、G1-G4各组间差异均有统计学意义(P<0.05),在S4期下降到正常值以下(95.08±20.57)。RBC、WBC二项指标在S3、S4与S0、S1和S2之间有统计学意义(P<0.05),在G4与G1、G2、G3之间有统计学意义(P<0.05)。结论RBC、WBC和PLT与肝组织纤维化和炎症程度负相关,PLT相关性最好,PLT降至正常界值以下,提示肝组织存在早期肝硬化,PLT下降接近正常界值下限时,提示肝组织的炎症活动和纤维化程度均很严重。Objective To study the relation between peripheral blood cell count,and inflammation grade （G） and fibrosis stage（S） in patients with chronic hepatitis B （CHB）.Methods 398 CHB patients were divided into 5 groups （S_0～S_4） according to liver fibrosis stages,and 4 groups （G_1～G_4） according to liver inflammation grades.The levels of RBC,WBC and PLT were analysed.Results The liver fibrosis stages and the degree of inflammation were negatively correlated with RBC,WBC and PLT counts.The spearman correlation coefficients of PLT with the liver fibrosis stages and liver inflammation grades were 0.743（P0.05） and 0.688 （P0.05）,respectively.The amount of PLT was significantly different between S_0～S_4 and G_1～G_4,and the PLT count was less than normal （95.08±20.57） in S_4.There was a statistically significant differences in the levels of RBC and WBC between S_3 and S_4,and S_0,S_1 and S_2 （P0.05）,furthermore a significant difference also observed between G_4,and G_1,G_2 and G_3 （P0.05）.Conclusion The levels of RBC,WBC and PLT are negatively correlated with liver fibrosis stages and inflammation grades.The decrease of PLT to less than normal might be used as predictive value for early cirrhosis.

关 键 词：乙型肝炎 肝组织 血细胞计数 

分 类 号：R512.62[医药卫生—内科学]