慢性乙型肝炎患者血清脂联素水平与肝功能及相关因素的关系  

The relation between serum adiponectin levels and liver function correlated factors in patients with chronic hepatitis B

作　　者：张贵利[1] 李强[1] 李友生[1] 谭丽杰[1] 张宏[1] 刘石萍[2] 樊艳菊 周淑芳[1] 

机构地区：[1]邯郸市传染病医院肝一科 [2]邯郸市中心医院,河北邯郸056002

出　　处：《临床肝胆病杂志》2010年第2期184-186,共3页Journal of Clinical Hepatology

基　　金：邯郸市科学技术研究与发展计划资助项目(0923108051-5)

摘　　要：目的探讨慢性乙型肝炎(CHB)患者血清脂联素水平与肝功能及相关因素的关系。方法选择77例不同类型CHB患者,应用ELISA法检测血清脂联素水平;同时检测肝功能、血脂、空腹血糖(FBG)、HBVDNA等。测量人体身高、体重,计算体重指数(BMI)。30例健康体检者为正常对照组。结果各组CHB患者血清脂联素水平明显高于正常对照组(P<0.01),随肝损害加重而上升。脂联素与AST、TBil和ALP均正相关,与白蛋白(ALB)负相关。结论CHB患者血清脂联素水平升高与肝脏炎症活动有关,可能是机体抵抗炎症的一种机制。Objective To investigate the relationship between serum adiponectin levels,and liver function tests and other correlated factors in patients with chronic hepatitis B（CHB）.Methods 77 CHB patients and 30 healthy controls were enrolled in the study.Serum adiponectin was detected by ELIS,and height and body weight measurement,liver function tests,blood lipid,fasting serum blood glucose（FBS）and HBV DNA levels were quantified,simultaneously.Results Serum adiponectin level in CHB patients was significantly higher than the normal control group （P0.01）,and increased with the severity of the disease.Serum adiponectin was positively correlated with aspartate aminotransferase（AST）,total bilirubin（TBIL）and alkaline phosphatase（ALP）,and negatively correlated with albumin（ALB）.Conclusion High adiponectin level in CHB patients is correlated with the liver inflammation,and it could be a marker for the body＇s anti-inflammatory mechanisms.

关 键 词：脂联素 乙型肝炎 慢性 肝功能 

分 类 号：R512.62[医药卫生—内科学]