间充质干细胞诱导移植耐受的研究进展及可能机制(英文)  

Research progress and possible mechanisms of transplantation tolerance induced by mesenchymal stem cells

作　　者：张雅永[1,2] 蒋立虹[1,2] 侯宗柳[1,2] 

机构地区：[1]昆明医学院附属延安医院 [2]昆明市延安医院心胸外科,云南省昆明市650051

出　　处：《中国组织工程研究与临床康复》2010年第14期2652-2656,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：Yunnan Provincial Social Development Science and Technology Program,No.2007CA005~~

摘　　要：背景:间充质干细胞能自我更新、高度增殖,具有多向分化潜能、低免疫原性及免疫调节特性。在体内和体外均能调节同种异体免疫反应,在实体器官移植中发挥着重要作用,有望成为诱导移植耐受的新途径。目的:综述间充质干细胞在实体器官移植中的应用及其免疫调节机制的最新进展。方法:应用计算机检索Pubmed 1994-01/2009-10期间相关文章,运用MeSH主题词检索,检索词为"Mesenchymal Stem Cells,Mesenchymal Stem Cell Transplantation,Organ Transplantation,Transplantation Immunology,Immunologic Graft Enhancement,Graftvs Host Disease",并限定文章语言种类为"English"。同时计算机检索万方数据库1994-01/2009-10期间相关文章,检索词为"间充质干细胞、器官移植、移植免疫"。纳入标准:文章所述内容应与间充质干细胞免疫学特性、器官移植中的应用及移植免疫进展研究相关。排除标准:重复研究或Meta分析类文章。结果与结论:共收集到200篇相关文献,86篇文献符合纳入标准。间充质干细胞具有低免疫原性及调节免疫调节特性,在诱导移植耐受和器官移植后组织修复中有着不可或缺的优势,其诱导免疫耐受的机制可能与可溶性因子、调节性T细胞、耐受性树突细胞、骨髓嵌合状态、抗炎和组织修复功能有关,并受间充质干细胞输入方式、剂量与时间的影响。BACKGROUND：Mesenchymal stem cells are capable of self-renew,a high degree of proliferation,with multi-differentiation potential,low immunogenicity and immunomodulatory properties.Both in vivo and in vitro it is able to regulate allogeneic immune response,to induce immune tolerance.In the solid organ transplantation it is playing an increasingly important role.OBJECTIVE：To summarize the research progress on the immunomodulatory mechanism and application of mesenchymal stem cells in solid organ transplantation.METHODS：An online search of Pubmed was undertaken by using the key words of ＂Mesenchymal Stem Cells,Mesenchymal Stem Cell Transplantation,Organ Transplantation,Transplantation Immunology,Immunologic Graft Enhancement,Graft vs.Host Disease＂ in Mesh to identify the relevant articles published in English from January 1994 to October 2009.At the same time,Wanfang database was screened to identify the relevant articles published between January 1994 and October 2009 with the key words of ＂Mesenchymal Stem Cells,Organ Transplantation,Transplantation Immunology＂ in Chinese.Inclusive criterion：The articles related to the immunomodulatory properties,transplantation immunology and application of mesenchymal stem cells in the solid organ transplantation were included.Exclusive criterion：The articles with repetitive research or Meta analysis were excluded. RESULTS AND CONCLUSION：Totally 200 relevant articles were selected and 86 of them met the inclusive criterion.Mesenchymal stem cells exhibit low immunogenicity and immunomodulatory properties,have an indispensable advantage about inducing graft tolerance and repairing tissue in solid organ transplantation.The mechanism of inducting immune tolerance may be related to soluble factors,regulatory T cells,tolerant dendritic cells,bone marrow chimerism,anti-inflammatory and tissue repair,dose and time of injecting MSCs.

关 键 词：移植免疫 移植耐受 移植 间充质干细胞 干细胞 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]