同种异体人心脏主动脉与肺动脉瓣膜的生物力学比较  

Comparison of biomechanical properties between human aortic and pulmonary valves

作　　者：崔彬[1] 刘迎龙[1] 谢宁[1] 张恩平[2] 

机构地区：[1]中国医学科学院,北京协和医学院,阜外心血管病医院心血管外科,心血管病研究所,北京市100037 [2]北京工业大学生物医学工程学院,北京市100040

出　　处：《中国组织工程研究与临床康复》2010年第18期3352-3354,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:目前同种心脏瓣膜已成熟应用于瓣膜替换手术及复杂先天性心脏病矫治手术中,但人心脏肺动脉瓣膜与主动脉瓣膜生物力学特性的对比研究报道较少。目的:对比分析深低温液氮保存人心脏主动脉瓣膜和肺动脉瓣膜的生物力学特性。方法:对比观察试验于2004-03/07在中国医学科学院心血管病研究所先天性心脏病研究室完成。取深低温液氮保存的健康成年男性脑死亡6h内志愿捐献者的人心脏主动脉瓣膜和肺动脉瓣膜各6例,符合医学伦理学要求。应用HD-10型厚度仪测定瓣膜组织的厚度,应用Instron拉伸机测定周向瓣膜组织的生物力学参数:瓣膜组织的断裂强度、应力应变曲线的斜率及伸长比。结果与结论:与人主动脉瓣膜相比,人肺动脉瓣膜组织厚度明显变薄;但二者的生物力学参数瓣膜组织的断裂强度、应力应变曲线的斜率及伸长比差异均无显著性意义(P>0.05)。结果提示,人主动脉瓣膜与肺动脉瓣膜的生物力学特性基本相似,从瓣膜水平上分析,人肺动脉瓣膜可满足主动脉瓣位生物力学的需要。BACKGROUND：The human homograft valve has been widely used in the operation of the valve replacement and congenital heart disease.However,reports concerning pulmonary valve biomechanical suitability as a long-term substitute for aortic valve are limited.OBJECTIVE：To compare the biomechanical properties between human aortic and pulmonary valves conserved with ultra low temperature in liquid nitrogen.METHODS：A contrast observation trial was conducted in the laboratory of Congenital Heart Disease of Fuwai Hospital from March to July in 2004.Six samples of heart aorta valves and pulmonary valves were collected from the cadaveric heart within 6 hours,and the experimental procedure was disposed according to ethical criteria.The biomechanical properties of the circumferential direction of the valve were investigated using uniaxial tensile tests.The thickness of the valve was measured by HD-10 thickness instruments.RESULTS AND CONCLUSIONS：Compared to human aortic valves,the thickness of the human pulmonary valves was thinner significantly,but the stress-strain,tensile strength and the maximum tangent modulus E（the slope of linear segment）in the curve had no significant difference（P 0.05）.Biomechanical differences between the aortic and pulmonary valve are minimal,in respect,pulmonary valve can be considered biomechanically suitable for aortic valve replacement.

关 键 词：主动脉瓣膜 人 肺动脉瓣膜 生物力学 心脏 

分 类 号：R318[医药卫生—生物医学工程]