极高血浆脑钠素水平的临床意义  

The Significance of Very High Level of Plasma Brain Natriuretic Peptide in Patients with Congestive Heart Failure

作　　者：张春红[1] 黄党生[1] 沈东[1] 张许文[1] 张丽伟[1] 孙红岩[1] 白静[1] 

机构地区：[1]解放军总医院第一附属医院心内科,北京100048

出　　处：《医学研究杂志》2010年第4期88-89,共2页Journal of Medical Research

摘　　要：目的本研究主要探讨血浆极高值BNP水平时患者的临床情况,及BNP对患者的预后意义。方法对我院2003年9月～2005年12月期间住院患者,行BNP检测,其中>5000ng/L的患者共13例,男性8例,女性5例,平均年龄72±8.7岁,分析这些患者的临床情况,观察2年内的病死率。结果 13例患者均有多器官功能障碍,多为疾病的终末期,3个月内病死率53.8%,2年内共死亡9例,2年病死率为69.2%。结论 BNP水平是心力衰竭患者死亡危险增加的一个生化指标,是影响患者预后的一个重要危险因素。ObjectiveTo evaluate the clinical status and prognostic value of very high B-type natriuretic peptide level. MethodsPlasma level of BNP in patients with heart failure was measured between 2003 and 2005. BNP〉5000μg/L was found in 13 patients. All cause mortality was examined during follow up. ResultsAll the 13 patients had multiple organ dysfunction at the end stage of the disease. During follow up,7（53.8%） patients died in the 3 months, and 9 （62.9%）patients died in two years. ConclusionThe plasma BNP concentration appears to be a biochemical marker of an increased risk of all-cause mortality in patients with heart failure, especially multiple organ dysfunction.

关 键 词：脑钠素 心功能不全 病死率 多器官衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]