人血清ANGPTL3含量与高血脂、高血糖的相关性  

Relationship of Angiopioetin-like Protein 3 Content in Human Sera to Hyperlipemia and Hyperglycemia

作　　者：肖亚雄[1,2,3] 王继红[1,2,3] 孔渝菡[4] 

机构地区：[1]重庆医科大学实验教学中心生物化学与分子生物学实验室,重庆400016 [2]重庆医科大学基础医学院生物化学与分子生物学教研室,重庆400016 [3]重庆医科大学分子医学与肿瘤研究中心,重庆400016 [4]重庆医科大学附属第一医院神经病学实验室,重庆400016

出　　处：《中国生物制品学杂志》2010年第4期422-424,共3页Chinese Journal of Biologicals

基　　金：重庆市科委自然科学基金(CSTC;2008CE9142);重庆医科大学创新基金(CX200528)

摘　　要：目的分析高血脂、高血糖及高血糖合并高血脂患者血清ANGPTL3含量与人类脂代谢、糖代谢紊乱的相关性。方法根据体检结果将观察对象分为健康对照(C)组、高血脂(HL)组、高血糖(HG)组和高血糖合并高血脂(HG-HL)组,采用双抗体夹心ELISA法检测各组血清ANGPTL3含量。结果HL、HG及HG-HL组患者血清ANGPTL3含量明显高于C组,且差异有统计学意义;仅HG组女性血清ANGPTL3含量显著高于男性,其余各组男性与女性血清ANGPTL3含量差异无统计学意义。结论高血脂、高血糖及高血糖合并高血脂人群血清ANGPTL3水平高于正常人,ANGPTL3可能在人类糖和脂类代谢紊乱的发病过程中发挥重要作用。Objective To analyze the relationship of ANGPTL3 content in sera of patients with hyperlipemia（HL）, hyperglycemia（HG）and HG complicated with HL（HG-HL）to glycometabolism and lipid metabolism disturbances in humans. Methods The subjects were divided into healthy control （C）, HL, HG and HG-HL groups according to the results of physical examination, and determined for serum ANGPTL3 content by double antibody sandwich ELISA. Results The serum ANGPTL3 contents of subjects in HL, HG and HG-HL groups were significantly higher than those in C group. However, only the serum ANGPTL3 content in HG group was significantly higher in female subjects than in male subjects, while those in other groups showed no significant difference. Conclusion The ANGPTL3 levels in sera of patients with HL, HG and HG-HL were significantly higher than those in healthy persons, indicating that ANGPTL3 might play an important role in the onset of glycometabolism and lipid metabolism disturbances in humans.

关 键 词：血管生成素样蛋白3 高血脂 高血糖 

分 类 号：R589.1[医药卫生—内分泌] R589.2[医药卫生—内科学]