帕瑞昔布钠治疗术后疼痛的临床观察  

Observation of Parecoxib for Postoperative Analgesia

作　　者：邓新波[1] 许太武[1] 孙臻[1] 

机构地区：[1]昆明医学院第二附属医院麻醉科,云南昆明650101

出　　处：《昆明医学院学报》2010年第3期89-91,共3页Journal of Kunming Medical College

摘　　要：目的探讨帕瑞昔布钠对于术后疼痛的治疗.方法80例ASAⅠ～Ⅱ级择期行胆囊切除术,按手术方式分为腹腔镜组(又分为Ⅰ、Ⅱ两组,每组n=20)和开腹组(又分为Ⅲ、Ⅳ两组,每组n=20),所有病人均采用全麻插管靶控全凭静脉麻醉,Ⅰ组、Ⅲ组术毕前10 min分别静脉给予帕瑞昔布钠(特耐)40 mg,Ⅱ组、Ⅳ组为对照组未给予.评估术后60 min疼痛强度(Prince-Henry评分)、镇痛补救措施、观察不良反应等.结果术后60 min内的各时段Ⅰ、Ⅱ组病人评分比较P<0.05;Ⅲ、Ⅳ组病人比较评分P>0.05,镇痛补救措施差异无统计学意义(P>0.05).在清醒室观察及术后24 h未发现病人消化道、凝血功能变化出现症状.结论术毕静脉给予帕瑞昔布钠(特耐)40 mg有一定镇痛作用,但是非甾体类抗炎镇痛药镇痛疗效较弱,尤其是有手术切口更不适合单独使用.Objective To investigate the efficacy of parecoxib for postoperative analgesia.Methods Eighty ASAⅠ-Ⅱ patients scheduled for laparoscopic cholecystectomy under general anesthesia were randomly divided into 2 groups（n=40 each） ： laparoscope group and open group.Laparoscope group was divided into 2 subgroups（n=20 each）：group Ⅰ and groupⅡ.Open group was also divided into 2 subgroups（n=20 each）： group Ⅲ and group Ⅳ.A single dose of parecoxib 40 mg was given to patients 10 min before operation in group Ⅰ and Ⅲ.The patients in group Ⅱ and Ⅳ were served as control and received normal saline instead.The pain intensity 60 min after surgery was assessed using Prince-Henry score（PHS）.The adverse reactions were observed.Results The PHS was significantly lower in group Ⅰ than in group Ⅱ（P0.05）.The PHS was not significantly lower in The PHS was significantly lower in group Ⅰ than in group Ⅱ（P0.05）.The allocation of extra analgetics was similar in groupⅠthan in groupⅡand in group Ⅲ than in groupⅣ（P0.05）.No patient had the symptoms of gastrointestinal tract and changes in blood coagulation function during the observation in the recovery room and 24 h after surgery.Conclusion Parecoxib has analgesiceffect after cholecystectomy but the effect is not potent,so parecoxib is not suitable to use singly after operation.

关 键 词：环氧化酶抑制剂 镇痛 胆囊切除术 

分 类 号：R971.105[医药卫生—药品]