辛伐他汀与骨粉复合物填充大鼠胫骨骨缺损修复作用的实验研究  被引量:2

Experimental Study on Bone Formation in Defect of Rats Tibia by Simvastatin-Biooss Complex

在线阅读下载全文

作  者:刘志强 周东风[2] 周磊[2] 王春先[2] 邹剑曾 李东健 

机构地区:[1]广州市荔湾区口腔医院,广东广州510170 [2]广东省口腔医院.南方医科大学附属口腔医院

出  处:《广东牙病防治》2010年第4期179-183,共5页Journal of Dental Prevention and Treatment

基  金:广东省自然科学基金项目(32569)

摘  要:目的研究辛伐他汀作为激活物对大鼠胫骨骨缺损修复的促进作用。方法实验组用辛伐他汀与Bio-Oss骨粉复合物填入大鼠胫骨骨缺损模型,对照组骨缺损单纯填入Bio-Oss骨粉,空白组骨缺损部位不放入骨粉。术后4、8、12周分别处死大鼠,定性、定量分析,观测骨增量变化和骨缺损修复进程。结果空白组无法正常愈合;实验组在新骨生成和改建速度上明显好于对照组。结论辛伐他汀有促进新骨生成作用,加速了骨缺损修复进程。Objective To study stimulation of bone formation by statins (simvastatin) as an activation. Methods Seventy-two SD rats (3 mm defect of left tibia) were random divided into three groups including ①untreated group; ②control group(defect of tibia filled with Bio-Oss alone); ③experiment group: (defect of tibia filled with Simvastatin-Biooss complex). The rats were sacrificed at 4, 8 and 12 weeks and the bone formation was observed. Results The differences among groups were obvious at 8 and 12 weeks. When group 2 and 3 was compared, the bone formation of group 3 was better in both quality and velocity. Conclusion Simvastatin can improve bone formation as an activation in defect of rats tibia.

关 键 词:辛伐他汀 骨缺损 成骨作用 

分 类 号:R318.08[医药卫生—生物医学工程]

 

参考文献:

正在载入数据...

 

二级参考文献:

正在载入数据...

 

耦合文献:

正在载入数据...

 

引证文献:

正在载入数据...

 

二级引证文献:

正在载入数据...

 

同被引文献:

正在载入数据...

 

相关期刊文献:

正在载入数据...

相关的主题
相关的作者对象
相关的机构对象