各临床类型肝炎患者Th1/Th2变化意义的初步探讨  

Changes of Th1/Th2 in Patients with Different Types of Viral Hepatitis

作　　者：陈湖光[1] 余春艳[1] 马亦林[1] 

机构地区：[1]浙江医科大学附属第一医院传染科

出　　处：《暨南大学学报（自然科学与医学版）》1998年第6期127-128,共2页Journal of Jinan University(Natural Science & Medicine Edition)

摘　　要：Ｔｈ１和Ｔｈ２所分泌的具有代表性主要细胞因子分别为γ－ＩＦＮ和ＩＬ－４。在目前国内尚无条件测定Ｔｈ１／Ｔｈ２细胞表面标记的情况下，检测ｒ－ＩＦＮ和ＩＬ－４可大体了解Ｔｈ１／Ｔｈ２功能。本研究应用ＥＬＩＳＡ方法，采用晶美公司试剂，对不同临床类型病毒性肝炎患者清中γ－ＩＦＮ、ＩＬ－４及其比值进行检测和分析。结果发现：急性肝炎患者中，血清γ－ＩＦＮ和ＩＬ－４均明显提高，但前者提高的幅大于后者，故γ－ＩＦＮ／ＩＬ－４比值也提高。与之相比较，慢性肝炎患者血清中γ－ＩＦＮ和ＩＬ－４均明显减少，但因前者减少的程度大于后者，故γ－ＩＦＮ／ＩＬ－４比值明显降低。在重症肝炎患者中，血清γ－ＩＦＮ显著下降而血清ＩＬ－４显著增高，致使γ－ＩＦＮ／ＩＬ－４比值严重倒置。三型中γＩＦＮ的浓度从高到低依次为：急性、慢性、重症。ＩＬ－４的浓度依次为：急性、重症、慢性。γ－ＩＦＮ／ＩＬ－４比值的高低依次为：急性、慢性、重症ｈ１通过释放γ－ＩＦＮ而介导细胞免疫，Ｔｈ２则经ＩＬ－４介导体液免疫。Ｔｈ１／Ｔｈ２比值的平衡是维持正常免疫功能的重要因素。本研究结果表明Ｔｈ１／Ｔｈ２与病毒性肝炎疾病的转归有密切的关系。Ｔｈ１功能的增强有助于疾病好转，?Serum γ-IFN/IL-4 from patients with different types of viral hepatitis were investigated by the method of ELISA. The results showed as following:in those with acute hepatitis,serum γ-IFN and IL-4 were both elevated signiticantly,forming a higher γ-IFN/IL-4 ratio due to more remarkably increasing of γ-IFN than IL-4;in those with chronic hepatitis,there was a obviously decrease of γ-IFN/IL-4 ratio with a greater degree of drop in γ-IFN than in IL-4;in those with grave hepatitis,the ratio reverted seriously because of decreasing γ-IFN accompanied by increasing IL-4. γ-IFN/IL-4 can presents roughly Th1/Th2 function. Th1 mediates cellular immunity and Th2 mediates hormonal immunity. The results of this paper suggested that heightened Th1 function might be benefit to recover from viral hepatitis, whereas excessive Th2 function be harmful. And Th1/Th2 ratio might have a close correlation to the severity and prognosis of the illness.

关 键 词：肝炎 病毒性肝炎 TH1细胞 TH2细胞 

分 类 号：R512.6[医药卫生—内科学]