强直性脊柱炎易感性与IL-1F10基因多态性关系  

Association between interleukin-1F10 gene polymorphism and susceptibility of ankylosing spondylitis

作　　者：廖芳芳[1] 潘发明[1] 夏果[1] 徐胜前[2] 徐建华[2] 梅杨[1] 葛锐[1] 朱立炜[1] 

机构地区：[1]安徽医科大学流行病与卫生统计学系,合肥230032 [2]安徽医科大学第一附属医院风湿科

出　　处：《中国公共卫生》2010年第4期421-423,共3页Chinese Journal of Public Health

基　　金：国家自然科学基金(30771849;30972530);2008年科技厅年度科研计划资助基金(08020303070);安徽医科大学博士启动基金(01XJ2006001);安徽省自然科学基金(090413133)

摘　　要：目的探讨强直性脊柱炎易感性与白细胞介素-1F10(IL-1F10)基因中rs6743376和rs6761276位点基因多态性的关系。方法收集2007-2008年安徽医科大学附属第一医院门诊确诊的强直性脊柱炎患者161例和同期正常健康献血人群对照178人,采用基于高温连接酶的连接酶检测反应(LDR)方法检测其IL-1F10 rs6743376和rs6761276位点的单核苷酸多态性,分析比较其等位基因频率及基因型频率在2组中的分布。结果病例组和对照组的rs6743376位点A等位基因频率分别为74.2%,71.6%;C等位基因频率分别为25.8%,28.4%;2组的rs6761276位点C等位基因频率分别为21.1%,18.0%;T等位基因频率分别为78.9%,82.0%;2个位点等位基因在2组人群中的分布差异均无统计学意义(均P>0.05);基因型频率在2组间的分布差异也无统计学意义。结论安徽籍汉族人群强直性脊柱炎易感性与IL-1F10基因rs6743376和rs6761276位点单核苷酸多态性无关。Objective To investigate the association between the interleukin-1F10（IL-1F10）,gene polymorphism and ankylosing spondylitis（AS）.Methods The polymorphisms of IL-1F10（rs6743376 and rs6761276）gene was analysed in 178 AS patients from a grade III level A hospital of Anhui province and 161 health controls with ligase detection reaction based on high temperature ligase.The distribution of rs6743376 and rs6761276 genotypes and allele frequencies were detected in the two groups.Results No significant difference was found in the distribution of rs6743376 and rs6761276 genotypes and allele frequencies between AS patients and health controls.Conclusion Our study suggests that the two single nucleotide polymorphisms（rs6743376 and rs6761276 of IL-1F10） may not be a susceptibility factor for AS in Anhui Han population.

关 键 词：强直性脊柱炎 白细胞介素-1F10基因 基因多态性 

分 类 号：R593.23[医药卫生—内科学]