整合素连接激酶与整合素  

Integrin-Linked Kinase and Integrin

作　　者：熊涛[1] 屈艺[1] 母得志[1] 

机构地区：[1]四川大学华西第二医院儿科,成都610041

出　　处：《实用儿科临床杂志》2009年第23期1848-1851,共4页Journal of Applied Clinical Pediatrics

基　　金：国家自然科学基金项目资助(30770748);国家杰出青年科学基金项目资助(30825039);四川省青年科技基金项目资助(08ZQ026-069)

摘　　要：整合素是位于细胞表面的重要黏附分子,激活后通过胞内效应器发挥作用。整合素连接激酶(ILK)是一种定位于黏着斑的苏氨酸/丝氨酸蛋白激酶,是整合素胞外-胞内信号传导中极为重要的效应器及众多生化信号通路中的枢纽。ILK在机体多种器官的生理和病理状况下,如细胞-基质交互作用,细胞生长、增殖、存活、分化,肿瘤转移、浸润和血管形成中发挥重要作用。Integrin is a kind of crucial adhesive molecule on the membrane,and it exerts its function through activating its intra-cellular effectors.One of the most important effectors is integrin-linked kinase （ILK）,which is a serine/threonine protein kinase located in focal adhesions and has a key position in transducing many of the biochemical signals.It plays an important roles in regulating fundamental processes such as cell-matrix interactions,growth,proliferation,survival,differentiation,migration,invasion and angiogenesis under both physilogical and pathological processes.

关 键 词：整合素连接激酶 整合素 信号通路 

分 类 号：R341[医药卫生—基础医学]