复方醋酸地塞米松乳膏质量标准研究  

Study on Quality standards for compound Dexamethasone Acetate Cream

作　　者：刘萍[1] 赵雪娥[1] 

机构地区：[1]四川省凉山州第一人民医院药剂科,四川西昌615000

出　　处：《医学信息（中旬刊）》2010年第4期756-758,共3页Medical Information Operations Sciences Fascicule

摘　　要：目的:建立复方醋酸地塞米松乳膏的质量标准。方法:采用TLC法建立了处方中醋酸地塞米松的鉴别项;采用化学反应法建立了尿素的鉴别项;采用HPLC法建立了醋酸地塞米松的含量测定项。结果:醋酸地塞米松在0.0622～0.5598μg范围内呈良好的线性关系,γ=0.99997,平均回收率为100.79%,RSD%为1.10%。结论:方法简便、准确,重现性好,能有效控制该制剂质量。Objective：To establish the quality standards for compound Dexamethasone Acetate Cream.Methods：Dexamethasone Acetate was identified by TLC.Urea was identified by chemistry method. The content of Dexamethasone Acetate was determined by HPLC.FlesultS：Dexamethasone Acetate could be identified by TLC.Urea could identified by chemistry method.The determination of Dexamethasone Acetate showed a good linear relationship in the range of 0.0622-0.5598μg,r=0.99997.The average recovery was lO0.79%,RSD was 1.10%.Conclusion：The method is simple and accurate. It can be used for quality control of compound Dexamethasone Acetate Cream.

关 键 词：复方醋酸地塞米松乳膏 醋酸地塞米松 尿素 薄层色谱 化学反应 HPLC法 

分 类 号：R986[医药卫生—药品]