P糖蛋白表达对HIV-1蛋白酶抑制剂在体内吸收与分布的影响  

The Role of P-Glycoprotein Expression on Absorption and Distribution of HIV-1 Protease Inhibitors

作　　者：姚瑶[1] 胡卓汉[1] 

机构地区：[1]上海医药工业研究院国家上海新药安全评价研究中心,上海201203

出　　处：《中国现代应用药学》2010年第4期312-315,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的通过介绍体内各屏障高度表达的P糖蛋白外排作用对HIV-1蛋白酶抑制剂的影响,探讨如何通过有效调节P糖蛋白,优化对艾滋病患者的治疗。方法查阅国外文献进行总结和归纳。结果综述了P糖蛋白表达对HIV-1蛋白酶抑制剂在体内吸收、分布的影响。结论 P糖蛋白一定程度地阻碍了HIV-1蛋白酶抑制剂在体内的吸收和分布,通过抑制P糖蛋白的活性,可以增加HIV-1蛋白酶抑制剂的化学疗效,未来艾滋病的治疗,P糖蛋白抑制剂的选择和使用将是一项艰巨的任务。OBJECTIVE By introducing the effiux function of P-glycoprotein（P-gp）, the way to optimize the treatment of HIV-1 infection by modulation of P-gp was discussed. METHODS Searching and summarizing literatures about HIV-1 protease inhibitor and P-gp. RESULTS The effect of P-gp expression for HIV-1 protease inhibitor absorption and distribution was summarized. CONCLUSION P-gp can hamper the absorption and distribution ofHIV-1 protease inhibitor. The therapeutic effect of HIV-1 protease inhibitors can be improved by modulating P-gp properly, however, the selection and use of P-gp inhibitor will be an arduous mission in the future.

关 键 词：P糖蛋白 分布 屏障 

分 类 号：R962.2[医药卫生—药理学]