阿尔茨海默病中医病因病机探讨  

Discussion on Alzheimer disease pathology in Chinese medicine

作　　者：苏芮[1] 韩振蕴[2] 范吉平[3] 

机构地区：[1]北京中医药大学东直门医院,北京100700 [2]北京中医药大学东方医院,北京100078 [3]中国中医科学院,北京100700

出　　处：《中华中医药杂志》2010年第5期743-744,共2页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金资助项目(No.30701137)~~

摘　　要：历代医家已经认识到了肾精亏虚、痰浊瘀血在痴呆发病中的重要作用。随着人们对阿尔茨海默病的认识,以及"毒损脑络"理论的提出,笔者进一步提出阿尔茨海默病的重要病理产物β-淀粉样蛋白具有损伤脑髓的特点,属于内生浊毒范畴,浊毒损伤脑髓也是该病发病的重要机制。肾精亏虚是阿尔茨海默病发生的前提,脑髓失养与内生浊毒败坏脑髓两方面共同作用下,导致脑消髓减,神机失用是阿尔茨海默病的发病机制。Doctors of past dynasties already understood deficiency of kidney essence,phlegm and blood stasis were important for dementia.As the increasing recognition about Alzheimer disease and the offer of ＇toxin damaging brain vessel＇ hypothesis,we thought β-Amyloid,the pathology of Alzheimer disease,had the character of damaging brain and marrow,so it belonged to internal toxin,internal toxin damaging brain and marrow was also the pathology of the disease.Deficiency of kidney essence was the precondition,insufficient brain and marrow and internal toxin damaging brain and marrow were the two causes of brain and marrow consumption and spirit dysfunction,which were the pathology of Alzheimer disease in Chinese medicine.

关 键 词：阿尔茨海默病 肾精亏虚 脑髓失养 浊毒内生 败坏脑髓 

分 类 号：R277.7[医药卫生—中医学]