MTB新疆临床分离株MDR-TB和XDR-TB耐药情况初步调查  

Preliminary Investigation on the MDR-TB and XDR-TB of MTB Clinical Isolates From Xinjiang Area

作　　者：曹红艳[1] 吴长东[1] 米利古[1] 刘佩芝[2] 陈伟[1] 王远志[1] 李永祥[1] 袁俐[1] 

机构地区：[1]石河子大学医学院,新疆石河子832002 [2]石河子大学附属第一医院感染科,新疆石河子832008

出　　处：《现代生物医学进展》2010年第5期890-892,共3页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(30960356)

摘　　要：目的：分析新疆喀什地区结核分枝杆菌（MTB），临床分离株对4种一线和7种二线抗结核药物的耐药情况，初步探讨本地区耐多药结核病（MDR-TB）和广泛耐药结核病（XDR—TB）的流行情况。方法：收集2008．11．1～2009．10．31日期间新疆喀什地区结核病患者痰液标本，进行分离培养及菌种鉴定，并应用比例法对所分离得到的菌株进行耐药性检测。结果：102株分枝杆菌中，88株（86．3％）属于结核分枝杆菌复合群，7株（6．9％）属于牛型分枝杆菌，7株（6．9％）属于非结核分枝杆菌。对一种以上的抗结核药物具有耐药性的有20株，总耐药率为22．7％（20／88），耐多药率为6．8％（6／88），pre—XDR为33．3％（2／6），无XDR-TB病例。结论：新疆喀什地区结核病患者耐药率较高，在结核病治疗工作中应给予重视，尤其应加强对Pre—XDR的重视，以免发展成XDR-TB。Objective：By drug-susceptibility testing of clinical isolated Mycobacterium tuberculosis （M.TB） to four first-line and seven second-line anti-TB drugs, to know the situation of multidrug resistant tuberculosis（MDR-TB）and extensively drug-resistant tuberculosis （XDR-TB） in part areas of Xinjiang. Methods：The sputum samples of patients with TB were collected from Nov.lth, 2008 to Oet.31th, 2009 to conduct isolated culture and phenotypical classification, The anti-tuberculosis drugs were performed to detect the drug- resistance with the method of the proportion method. Results： 102 isolates were obtained, 88 strains （86.3%）were identified to M.TB complex isolates. Among 88 M.TB complex isolates, the general resistance rate to at least one drug were 22.7%. 6 isolates （6.8%） were found to be MDR-TB,2 isolates （33.3%） were found to be pre-XDR, and no XDR-TB was found in this study. Conelusion：Kashi Prefecture, Xinjiang, a higher rate of drug-resistant TB patients in TB treatment should be given full attention, in particular, should strengthen the importance of Pre-XDR, so to develop into XDR-TB.

关 键 词：结核分枝杆菌 耐药性 广泛耐药结核 

分 类 号：R521[医药卫生—内科学]