microRNAs对脂肪细胞分化相关因子的作用及预测  

Effect and Prediction of MicroRNAs on Relative Factor of Adipocyte Differentiation

作　　者：郑宏[1] 徐竞鸥[2] 于潇华[2] 周锋平[1] 欧和生[2] 

机构地区：[1]湘南学院附属医院,湖南郴州423000 [2]南华大学药理研究所,湖南衡阳421001

出　　处：《现代生物医学进展》2010年第5期972-974,981,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(30871186)

摘　　要：microRNAs是一类调节靶基因的转录后翻译的小型非编码单链RNA,研究已发现microRNAs在癌症、心血管疾病及糖尿病中显示极为重要的生物学功能。糖尿病目前已成为威胁人类健康的最主要疾病,尤其是II型糖尿病的发病机制成为研究热点。脂肪细胞分化异常是导致II型糖尿病以及胰岛素抵抗的主要因素。进一步阐明microRNAs对脂肪细胞分化过程的作用机制,可能为糖尿病治疗找到新的靶点。本综述将从microRNAs与脂肪细胞分化基因、核激素受体以及相关信号通路相互作用三方面阐述和预测microRNAs对脂肪细胞分化的潜在作用。rnicroRNAs are a class of single-stranded, non coding small RNA regulating posttranscriptional of target geneS. Recently research indicated the significant role of microRNAs in cancer, cardiovascular disease and diabetes. Diabetes is one of the most dangerous diseases which threats people＇s lives, especially the pathogenesis of type 2 diabetes increasingly became focus of studies. Abnormal adipocyte differetiation is the major factor of type 2 diabetes and insulin resistance. Further clarify mechanism of microRNAs in progress of adipocyte differetiation maybe helpful for new therapy targets. Protential role of microRNAs will be clarified and predicted following 3 aspects, including adipocyte differentiation relative gene, nuclear hormone receptor and relative signalling pathway.

关 键 词：mieroRNAs 脂肪细胞分化 潜在作用 

分 类 号：Q513[生物学—生物化学]