雌激素膜受体GPR30在成年雄性大鼠脊髓中的表达  

Expression of estrogen membrane receptor,G protein-coupled receptor 30 in the spinal cords of adult rats

作　　者：孙浩东[1] 胡荣[1] 冯华[1] 林江凯[1] 夏永志[1] 赵天智[1] 罗海水[1] 李兰[1] 

机构地区：[1]第三军医大学西南医院神经外科,重庆400038

出　　处：《中国临床神经外科杂志》2010年第4期228-230,共3页Chinese Journal of Clinical Neurosurgery

基　　金：国家自然科学基金(30872735)

摘　　要：目的研究雌激素膜受体—G蛋白偶联受体30(GPR30)在正常成年大鼠脊髓中的表达与分布。方法采用免疫组化染色法观察4只成年大鼠脊髓各节段中GPR30的表达和分布情况。结果在脊髓的各个节段,GPR30在脊髓中均有表达,但主要分布在灰质中,且以腹角为主,除腰段脊髓背角有少量GPR30阳性信号外,其余节段脊髓背角均未见明显GPR30阳性信号。GPR30在白质中的信号分布较均匀。结论GPR30在脊髓呈特异性分布,提示其在脊髓的生理和病理过程中可能起重要的作用。Objective To investigate the expression and distribution of estrogen membrane receptor,G protein-coupled receptor 30（ GPR30）in the spinal cords of the adult rats.Methods The expression and distribution of GPR30 in the spinal cords of 4 male adult ratsw ere determined by immunohistochemistry.Results GPR30-positive signal was detected in both the gray and white matter of 4 male rats pinal cord,in which GPR30 was mainly distributed in the gray matter,especially in its ventral horn.No significantly GPR30-positives ignal was detected in the dorsal horn of the spinal cord,except the lumbar spinal cord.Conclusion The distribution of estrogenm embrane receptor,GPR30 in spinal cord is specific.It is suggested GPR30 may pay a role in the some physiological and pathologicalp rocesses of the spinal cord.

关 键 词：大鼠 脊髓 雌激素 膜受体 GPR30 

分 类 号：Q786[生物学—分子生物学]