MicroRNAs在肿瘤和其它疾病诊断治疗中的应用  

Application of microRNAs in diagnosis and treatment of tumor and other diseases

作　　者：贾音[1] 张毅[1] 孙树汉[1] 

机构地区：[1]第二军医大学医学遗传研究所,上海200433

出　　处：《分子诊断与治疗杂志》2010年第2期123-127,共5页Journal of Molecular Diagnostics and Therapy

基　　金：国家自然科学基金项目(30901613);国家"十一五"科技支撑计划项目(2006BAI05A05);上海市科委基础研究重点项目(08JC1405300);上海市科委自然基金(09ZR1439100)

摘　　要：MicroRNAs(miRNAs)是一类内源性非编码小分子RNA,通过与靶mRNA3’端非翻译区完全或不完全互补配对,引起mRNA降解或翻译抑制,发挥基因调控作用。miRNAs在细胞增殖、分化、凋亡,个体发育等多种生物学过程中都起到重要作用,其表达失调可以导致疾病的产生。本文就miRNAs在肿瘤和其它疾病的发生、诊断等方面的研究进展作简要综述。miRNAs are endogenous,non-coding small RNAs that regulate gene expression by inducing translational inhibition or cleavage of their target mRNAs through base pairing at partially or fully complementary sites. miRNAs may play a critical role in many biological processes including cell proliferation,differentiation,apoptosis and ontogeny,miRNA deregulation may lead to disease. This article aims to review miRNAs in tumor and other diseases occurrence,diagnosis and other aspects of research.

关 键 词：肿瘤 疾病 MicroRNAs(miRNAs) 基因调控 

分 类 号：R450[医药卫生—治疗学]