淫羊藿总黄酮对去势大鼠骨密度的影响  

Effect of Epimedium Flavonoids on Bone Density of Ovariectomized Rats

作　　者：宋敏[1] 李晶[1] 李志锋[2] 

机构地区：[1]甘肃中医学院,兰州730000 [2]兰州军区总医院骨科研究所

出　　处：《浙江中西医结合杂志》2010年第5期273-275,共3页Zhejiang Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的:探讨淫羊藿总黄酮对去势大鼠骨密度的影响。方法:取10月龄雌性SD大鼠60只,随机分为正常组、模型组、雌激素组和淫羊藿低、中、高剂量组,每组10只。除正常组外,其余各组大鼠均行双侧卵巢切除术,术后1周分别给予生理盐水、淫羊藿总黄酮和雌激素进行干预,共90天,观察各组大鼠全身、股骨及腰椎骨密度的变化。结果:正常组和雌激素组大鼠全身骨密度均显著高于其他各组(P均<0.05);淫羊藿总黄酮低、中、高剂量组大鼠全身骨密度与模型组比较,差异无统计学意义(P>0.05);淫羊藿总黄酮低、中、高剂量组大鼠股骨骨密度显著高于模型组(P<0.05),淫羊藿总黄酮中、高剂量组大鼠腰椎骨密度显著高于模型组(P<0.05)。结论:淫羊藿总黄酮能明显抑制去势大鼠股骨及腰椎骨密度的降低,对去势大鼠全身骨密度无明显影响。Objective： To investigate the effect of epimedium flavonoids （EF） on bone density of ovariectomized rats. Methods： A total of 60 SD rats （female, 10 month ） were randomly divided into normal control, model, estrogen, and lowdose,medium- dose, and high-dose EF groups, 10 rats in each. Except the normal control group, rats in other groups were all ovariectomized bilaterally. Intervention measures were given for 90 days. The model group was injected with saline. Changes of total body, and femoral and lumbar vertebra bone density were observed and compared among the groups. Results：The total body bone density was significantly higher in the normal control and estrogen groups than it in the other groups （ P 〈 0.05 ） and no significant difference was noted between the EF groups and model group（ P 〉 0.05 ）. The femoral bone density in all EF groups was higher than that in the model group （ P 〈 0.05 ） and the lumbar vertebra bone density in the medium - and high - dose EF groups were higher than that in the model group （ P 〈 0. 05 ）. Conclusion： EF can suppress the reduction of femoral and lumbar vertebra bone density while do not effect the total body bone density in ovariectomized rats.

关 键 词：大鼠 去势 淫羊藿 淫羊藿总黄酮 骨密度 

分 类 号：R285.5[医药卫生—中药学]