参附注射液对开腹胆管手术患者细胞免疫、血清IL-2、TNF-α、CRP水平的影响  

Effects of Shenfu injection on T-lymphocyte subsets,interleukin-2,C-reactive protein and tumor necrosis factor-α in patients underwent biliary tract surgical procedure

作　　者：邵兰[1] 招伟贤[1] 陈研生[1] 肖健斌[1] 韦晨浦[1] 

机构地区：[1]广东省中医院麻醉科,广东广州510120

出　　处：《吉林医学》2010年第13期1742-1743,共2页Jilin Medical Journal

基　　金：广东省中医药局科研课题(2007040)

摘　　要：目的:观察参附注射液对开腹胆管手术患者T淋巴细胞亚群(CD4+、CD8+),白细胞介素-2(IL-2)、C-反应蛋白(CRP)和肿瘤坏死因子-α(TNF-α)的影响。方法:将30例胆管手术患者随机分为参附组(S组,参附注射液加手术组)及对照组(C组,单纯手术组)各15例,参附组术前予参附注射液50 ml静脉滴注,对照组行常规治疗。观察T淋巴细胞亚群、血清IL-2、CRP和TNF-α水平。结果:术后第1天参附组CD4+细胞和对照组相比明显升高(P<0.01),CD8+细胞在两组用药前后变化不明显。两组血清IL-2水平均有降低,参附组明显高于对照组(P<0.05);参附组血清TNF-α、CRP水平明显低于对照组(P<0.05,P<0.01)。结论:术前应用参附注射液能改善、调节胆管手术患者的免疫功能。Objective To explore the effect of Shenfu injection on T -lymphocyte subsets （CD4^＋ ,CD8^＋ ） ,interleukin -2 （IL -2） ,C - reactive protein （CRP） and tumor necrosis factor -α （ TNF -α） in patients underwent biliary tract surgical procedure. Method Total 30 cases were randomly divided into the control group （group C with 15 cases） and the shenfu group （group S with 15 cases）. Group S was treated by intravenous Shenfu injection （50 nil） and group C was treated by normal treatment. The levels of CRP and CD4^＋ ,CD8^＋ ,IL -2, CRP,TNF-α were measured. Results Compared with group C ,the levels of CRP,TNF-α in group S after operation were decreased obviously （ P 〈 0. 05, P 〈 0. 01 ）. IL - 2, CD4^＋ level after operation was increased significantly（ P 〈 0. 01 ）. Conclusion Shenfu injection can improve the immune function in patients underwent biliary tract surgery.

关 键 词：参附注射液 细胞免疫 白细胞介素-2 肿瘤坏死因子-α C-反应蛋白 

分 类 号：R269[医药卫生—中西医结合]