顶空气相色谱法测定乙基纤维素中有机溶剂残留量  

Determination of Residual Organic Solvent in Ethyl Cellulose by Headspace Capillary Gas Chromatography

作　　者：李春[1] 孙悦[2] 

机构地区：[1]天津市北辰区药品检验所,天津300400 [2]天津市药品检验所,天津300070

出　　处：《中国药业》2010年第8期48-49,共2页China Pharmaceuticals

摘　　要：目的建立乙基纤维素中残留有机溶剂二氯甲烷的测定方法。方法采用顶空进样毛细管气相色谱法,FID检测器,色谱柱为DB-624石英毛细管柱(30m×0.3mm,1.8μm),载气为氮气,柱温90℃。结果二氯甲烷可得到有效分离,在所考察的质量浓度范围内线性关系良好,r=0.9996(n=6),平均回收率为98.99%,RSD=1.04%(n=9)。结论所用方法灵敏、准确、快速,可作为乙基纤维素中残留有机溶剂二氯甲烷的检测方法 。Objective To establish a headspace capillary gas chromatography method for determining the residual organic solvent methylene chloride in ethyl cellulose. Methods Methylene chloride was separated on the DB-624 capillary column（30 m ×0. 3 mm, 1.8μm）,the column temperature was 90 ℃. Results Methylene chloride was separated with the good linearity, r = 0. 999 6（ n = 6）. The average recovery rate was 98.99%, RSD=1. 04% （n=9）. Conclusion The methods is proved to be accurate and sensitive after validation, which can be uses for determining the residual organic solvent methylene chloride in ethyl cellulose.

关 键 词：顶空气相色谱法 乙基纤维素 残留有机溶剂 

分 类 号：R927.11[医药卫生—药学] TQ460.4[化学工程—制药化工]