盐酸左氧氟沙星注射液与卡络磺钠注射液在0.9%氯化钠注射液中的稳定性研究  

Stability of levofloxacin hydrochloride injection and carbazo-chrome sodium sulfonate injection in 0.9% sodium chloride injection

作　　者：刘菁[1] 耿丽[1] 熊秋菊[1] 郑芳[1] 李志浩[1] 

机构地区：[1]郧阳医学院附属东风医院药剂部,湖北十堰442008

出　　处：《安徽医药》2010年第5期523-525,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的研究盐酸左氧氟沙星注射液与卡络磺钠注射液在0.9%氯化钠注射液中的稳定性,为临床合理用药提供依据。方法在室温(25±1)℃下,采用反相高效液相色谱法同时测定左氧氟沙星与卡络磺钠配伍后各时间点的含量,并测定pH,观察外观及性状。结果6 h内混合液外观、pH及含量均无明显变化。结论在室温(25±1)℃下,盐酸左氧氟沙星注射液与卡络磺钠注射液在0.9%氯化钠注射液中6 h内可以配伍使用。Aim To study the stability of levofloxacin hydrochloride injection and carbazochrome sodium sulfonate injection in 0.9% sodium chloride injection in order to supply evidence of clinical rational administration.Methods The assays of levofloxacin and carbazochrome sodium sulfonate were determined by RP-HPLC,and the outward appearance,pH were observed at ambient temperature（25±1）℃ within 6 hours.Results No obvious changes were found in the content,outward appearance and pH value for the mixed solution within 6 hours.Conclusion Levofloxacin hydrochloride injection and carbazochrome sodium sulfonate injection can be mixed in 0.9% sodium chloride injection under ambient temperature [（25±1）℃] within 6 hours.

关 键 词：盐酸左氧氟沙星 卡络磺钠 配伍 稳定性 反相高效液相色谱法 

分 类 号：R942[医药卫生—药剂学]