胃袖状切除对肥胖大鼠体重及Ghrelin、GLP-1、PYY_(3-36)水平的影响  

Influence of Sleeve Gastrectomy on Weight and Plasma Ghrelin,GLP-1 and PYY_(3-36) Levels in DIO Rats

作　　者：欧阳忠[1] 吴毅平[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院整形外科,武汉430030

出　　处：《华中科技大学学报（医学版）》2010年第2期225-227,235,共4页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

摘　　要：目的探讨胃袖状切除术的减肥作用及其机制。方法通过高脂饮食诱导SD肥胖大鼠,然后随机分为胃袖状切除(SG)组和假手术(SS)组。术后连续观察8周,比较两组术后体重、摄食和外周血Ghrelin、GLP-1、PYY3-36浓度的变化。结果SG组术后摄食量明显下降(P<0.05),体重连续3周持续下降,然后缓慢回升,至第8周时体重仍低于术前,外周血Ghrelin浓度下降,GLP-1和PYY3-36浓度升高(P<0.05),随着时间延长,血Ghrelin浓度逐渐升高,GLP-1和PYY3-36浓度逐渐回落。SS组术后食量、血Ghrelin、GLP-1和PYY3-36浓度无明显变化(P>0.05),8周后体重明显高于术前(P<0.05)。结论肥胖大鼠胃袖状切除术减重效果确切,术后Ghrelin浓度下降,GLP-1及PYY3-36浓度升高致使摄食量减少可能是其减肥的主要作用机制。Objective To investigate the weight-lowering mechanism of sleeve gastrectomy（SG）.Methods SD rats were fed on high-fat diet to induce obesity and randomly divided into experimental group（SG） and control group（sham operation）.During a follow-up period of 8 weeks,Rats＇ body weight,food intake and peripheral blood levels of Ghrelin,GLP-1,PYY3-36 were checked.Results In the experimental SG model,food intake was decreased（P0.05）;Postoperative weight continued to decline for three weeks and then slowly recover.Eight weeks later,body weight was still lower than that before the operation;Ghrelin was decreased,and GLP-1 and PYY3-36 increased（P0.05）.Over time,Ghrelin was gradually increased,and GLP-1 and PYY3-36 gradually declined.In the control group,postoperative weight was markedly increased after decline for one week.Eight weeks later,weight was significantly higher than that before operation;Food intake,Ghrelin,GLP-1 and PYY3-36 had no significant change（P0.05）.Conclusion The weight-lowering effects of SG in DIO rats are obvious.The postoperatively decreased Ghrelin,and increased GLP-1 and PYY3-36 are the major mechanism.

关 键 词：胃袖状切除术 饮食诱导肥胖大鼠 GHRELIN GLP-1 PYY3-36 

分 类 号：R656.611[医药卫生—外科学]