异维A酸联合克林霉素凝胶治疗痤疮的疗效观察  

Observation on the efficacy of isotretinoin combined with Clindamicin Phosphate Gel for the treatment of acne vulgaris

作　　者：华海康[1] 陶诗沁[1] 杨莉佳[1] 

机构地区：[1]南京医科大学附属无锡第二人民医院皮肤科,无锡214002

出　　处：《上海医药》2010年第5期237-239,共3页Shanghai Medical & Pharmaceutical Journal

摘　　要：目的:观察口服异维A酸与外用克林霉素磷酸酯凝胶联合治疗面部中度寻常痤疮的疗效。方法:将136例中度痤疮患者随机分为两组,治疗组70例采用口服异维A酸联合外用克林霉素磷酸酯凝胶治疗8wk;对照组单用克林霉素磷酸酯凝胶治疗8wk。结果:治疗组的总有效率为84.29%;对照组的总有效率为39.39%。经卡方检验,两组有极显著性差异(P<0.01)。结论:口服异维A酸联合外用克林霉素磷酸酯凝胶是治疗中度寻常痤疮的有效方法。Objective： To investigate the clinical effect of isotretinoin combined with Clindamicin Phosphate Gel in the treatment of moderate acne vulgaris. Methods： One hundred and thirty-six patients with moderate acne vulgaris were randomly divided into two groups. The treatment group received isotretinoin and Clindamicin Phosphate Gel for 8 weeks （n=70）.The control group received only Clindamicin Phosphate Gel for 8 weeks. Results： The total response rate was 84.29% in the treatment group and 39.39% in the control group. There was a statistical difference between the two groups （P 〈 0.01）. Conclusion： Oral administration of isotretinoin combined with external use of Clindamicin Phosphate Gel is effective for the treatment of moderate acne vulgaris.

关 键 词：寻常痤疮 异维A酸 克林霉素磷酸酯凝胶 

分 类 号：R758.733[医药卫生—皮肤病学与性病学]