地黄饮子对β淀粉样蛋白所致PC12细胞损伤的保护作用  

The Effect of DHYZ in Treating the Injury of PC12 Induced by Amyloid Beta-Protein

作　　者：周妍妍[1] 谢宁[1] 姚辛敏[1] 何秀丽[1] 

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药学报》2010年第2期19-21,共3页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金(30472128);高等学校博士学科点专项科研基金资助项目(20050228005)

摘　　要：目的:观察地黄饮子对β淀粉样蛋白(Aβ25-35)诱导的PC12细胞损伤的保护作用。方法:通过HE染色、尼氏染色、电镜观察地黄饮子对细胞形态的影响。结果:地黄饮子可显著改善Aβ25-35损伤引起的PC12细胞形态的改变,减轻细胞膜的损伤,减少损伤所致的细胞死亡。结论:地黄饮子对Aβ25-35所致PC12细胞损伤具有较好的保护作用。Objective：To investigate the effect of decoction of Rehmanniae on the injury of PC12 cell induced by Aβ（β-amyloid protein）. Methods： To investigate the change of conformation by HE Staining,Nissl＇s Staining and Electron microscope. Results： Decoction of Rehmanniae can prominently improve the conformation change of injurious PC12 cell, improve the cell energy,and reduce the injurious cellto death. Conclusion： Decoction of Rehmanniae canprotect the injurious cell.

关 键 词：Β淀粉样蛋白 PC12细胞 老年性痴呆 地黄饮子 

分 类 号：R285.5[医药卫生—中药学] R749.16[医药卫生—中医学]