芦柑皮挥发油等对胡椒碱促透作用研究  

Study on the Percutaneous Absorption of Piperine with Different Penetration-Orange Essential Oil

作　　者：李飞[1] 杨小林[2] 杨中林[1] 

机构地区：[1]中国药科大学,江苏南京210009 [2]武汉工业大学,湖北武汉430023

出　　处：《中医药学报》2010年第2期97-99,共3页Acta Chinese Medicine and Pharmacology

基　　金：科技部十一五科技支撑计划课题(编号:2006BAI06A11-14)

摘　　要：目的:比较研究芦柑皮挥发油和丁香挥发油对H巴布剂的透皮作用,以便为制备H巴布剂选择最佳促透材料。方法:采用体外Franz扩散池法,以兔皮为材料,以HPLC法测定含量,研究芦柑皮挥发油和丁香挥发油对H巴布剂中胡椒碱的透过量影响。结果:芦柑皮挥发油的促透量为(6.01±0.37)μg·cm-2,丁香挥发油的促透量为(4.46±0.28)μg·cm-2。结论:芦柑皮挥发油的促透效果优于丁香挥发油。Objective：To study the percutaneous absorption of H cataplasm with different penetration enhancers and to determine the best penetration enhancer to prepare the H cataplasm. Methods： Using rabbit skin as transdermal barrier,the penetration percentage of piperine in different cataplasm with different penetration enhancers-Clover Oil and Orange Essential Oil were determined with the Franz diffusing cells. The content of piperine permeated through the rabbit skin was determined by HPLC. Results： The Q of piperine with Clover Oil and Orange Essential Oil were 4. 46 ± 0. 28μg· cm-2,6. 01 ± 0. 37μg·cm-2 respectively. Conclusion： The penetration efficiency of Orange Essential Oil is better than Clover Oil.

关 键 词：巴布剂 丁香挥发油 芦柑皮挥发油 体外释放 

分 类 号：R285.5[医药卫生—中药学]