60例奈福泮联合芬太尼用于下腹部术后静脉镇痛的观察  

Evaluation of antalgic effects of intravenous nefopam combined with fentanil in patients after lower abdomen surgery in 60 cases

作　　者：郑庆国[1] 张云平[1] 郑成林[1] 秦绪强[1] 

机构地区：[1]徐州医学院附属第三医院麻醉科,江苏221003

出　　处：《重庆医学》2010年第9期1102-1103,共2页Chongqing medicine

摘　　要：目的观察奈福泮联合芬太尼用于下腹部术后镇痛的作用和不良反应。方法将60例符合美国麻醉医师协会(ASA)Ⅰ～Ⅱ级择期下腹部手术患者随机分为奈福泮组(N组)、芬太尼组(F组)和奈福泮复合芬太尼组(NF组),每组20例,将受奈福泮和芬太尼作为术后镇痛药物。记录开始镇痛后4、8、12、24、48 h 3组的疼痛视觉模拟评分(VAS)、Ramsay镇静评分(RSS)和治疗期间可能出现的不良反应。结果F、NF组患者术后各时间段VAS和RSS均优于N组。NF、N组术后恶心、呕吐等不良反应的发生率显著低于F组,差异有统计学意义(P<0.05)。结论奈福泮复合芬太尼用于下腹部术后镇痛是安全有效的,并且可以减少芬太尼的用量及其不良反应。Objective To assess the analgesic efficiency and adverse effects of postoperative intravenous analgesia with nefopam combined with fentanil in the patients undergoning lower abdomen surgery.Methods 60 ASA（american society of anesthesiologists） Ⅰ～Ⅱpatients who undertook lower abdomen operation were divided into three groups with 20 cases in each group.Nefopam group（group N）,fentanil group（group F）,nefopam combined with fentanil group（group NF） accepted nefopam and fentanil as the postoperative analgesics.The effectiveness was assessed with visual analogue scale（VAS） and Ramsay Sedation Score（RSS） at different time points：4,8,12,24,48 h after the beginning.The analgesic efficacy of analgesia and the adverse effects during analgesia period were observed.Results VAS and RSS in group F and group NF were significantly lower than those in group N at 4,8,12,24,48 h after operation（P〈0.05）.But the occurrence of PONV was significantly less in group N and group NF than that in group F（P〈0.05）.Conclusion Nefopam combined with fentanil is effective and safe for postoperative intravenous analgesia with the adavantages of reducing fentanil requirement.In addition,nefopam combined with fentanil has less adversed effects.

关 键 词：奈福泮 芬太尼 静脉镇痛 下腹部手术 

分 类 号：R614[医药卫生—麻醉学]