三氯苯达唑、吡喹酮治疗大鼠斯氏狸殖吸虫病的疗效观察  

Observation of the therapeutic efficacy of triclabendazole and praziquantel in treating rats with Pagumogonimus skrjabini

作　　者：严亚军[1] 王文林[2] 雷霖[2] 

机构地区：[1]武汉大学中南医院感染科,湖北武汉430071 [2]昆明医学院寄生虫学教研室,云南昆明650031

出　　处：《中国病原生物学杂志》2010年第4期283-285,共3页Journal of Pathogen Biology

摘　　要：目的观察三氯苯达唑、吡喹酮治疗大鼠斯氏狸殖吸虫病的疗效。方法将30只SD大鼠随机分成6组:三氯苯达唑治疗A组与B组、吡喹酮治疗A组与B组、对照A组与B组,每组5只大鼠。将斯氏狸殖吸虫囊蚴经腹腔注射感染6组大鼠,每只大鼠注射15个囊蚴。治疗A、B组分别于感染后30d和60d用相应药物治疗,用药后第3d剖杀大鼠,回收虫体,计数虫体回收数和虫囊数,计算检虫率及减虫率,并与对照组比较。结果三氯苯达唑治疗A组和吡喹酮治疗A组童虫检虫率分别为(20.00±4.72)%和(21.33±5.58)%,与对照A组(40.00±6.67)%比较,差异均有统计学意义(P<0.05);三氯苯达唑治疗A组和吡喹酮治疗A组童虫减虫率分别为50.00%和46.67%,差异无统计学意义(P>0.05);三氯苯达唑治疗B组和吡喹酮治疗B组成虫检虫率分别为(2.69±5.95)%和(22.60±8.95)%,与对照B组(53.33±9.43)%比较,差异均有统计学意义(P<0.05);三氯苯达唑治疗B组和吡喹酮治疗B组成虫减虫率分别为87.50%和57.50%,差异有统计学意义(P<0.05)。结论相同剂量与疗程的三氯苯达唑和吡喹酮治疗斯氏狸殖吸虫感染均有效,其中两药物杀灭斯氏狸殖吸虫童虫效果相似,杀灭成虫效果三氯苯达唑优于吡喹酮。Objective To observe the therapeutic effects of triclabendazole and praziquantel in treating rats infected with Pagumogonimus skrjabini.Methods Thirty rats were randomly divided into six groups：triclabendazole treatment groups A and B,praziquantel treatment groups A and B,and control groups A and B.There were 5 rats in each group.The 30 rats were each injected through the abdominal cavity with 15 metacercariae of P.skrjabini.Rats in treatment groups A and B were respectively treated on the 30th day and 60th day after infection with triclabendazole and praziquantel.Rats were dissected on the 3rd day after treatment.The number of worms recovered and worm cysts were counted,and the rate of worm recovery and rate of worm reduction were calculated.These indices were then compared among the groups.Results The rate of immature worm recovery for triclabendazole treatment group A,praziquantel treatment group A,and control group A was 20.00±4.72%,21.33±5.58%,and 40.00±6.67%,respectively;there was a significant difference between the two A treatment groups and control group A（P0.05）.The rate of worm reduction was 50.00% and 46.67% for triclabendazole treatment group A and praziquantel treatment group A,respectively;the difference between the two was not significant（P0.05）.The rate of adult worm recovery for triclabendazole treatment group B,praziquantel treatment group B,and control group B was 2.69±5.95%,22.60±8.95%,and 53.33±9.43%,respectively;there was a significant difference between the two B treatment groups and control group B（P0.05）.The rate of adult worm reduction was 87.50% and 57.50% for triclabendazole treatment group B and praziquantel treatment group B,respectively;the difference between the two was significant（P0.05）.Conclusion P.skrjabini was eradicated by the same doses and course of treatment with triclabendazole and praziquantel.The two drugs did not differ significantly in eradicating immature worms.Both drugs significantly eradicated adult worms,and triclabendazole had more of a

关 键 词：三氯苯达唑 吡喹酮 斯氏狸殖吸虫 大鼠 

分 类 号：R532.22[医药卫生—内科学]