黑质区神经降压素对纹状体多巴胺含量的影响  

EFFECTS OF NEUROTENSIN IN SUBSTANTIA NIGRA ON THE CONTENTS OF DOPAMINE IN STRIATUM

作　　者：陈蕾[1] 陈家津[1] 陈文芳[1] 周颖斌[1] 

机构地区：[1]青岛医学院生理学教研室,青岛266021

出　　处：《中国神经科学杂志》1998年第4期218-220,共3页

基　　金：山东省卫生厅赞助

摘　　要：采用荧光分光光度测定法，测定黑质区注射神经降压素及其抗血清对效状体等脑区多巴胺含量的影响。结果表明：（1）黑质区注射不同剂量的神经降压素后，纹状体内多巴胺含量较对照组明显增加，且呈明显的量效依赖关系，而下丘脑及大脑皮层内多巴胺含量无明显改变；（2）黑质区注射抗神经降压素血清后，级状体内多巴胺含且无明显改变。这提示，黑质区外源性神经降压素可增加效状体多巴胺的含量。The effects of microinjection neurotensin (NT) and anti-NT serum into substantia nigra on the contents of dopamine (DA) were measured by fluorometry. The results were shown: (1) The contents of DA in the striatum was increased in a dose-dependent way by injection of NT into the substantia nigra, but there were no change in hypothalamus and cerebral cortex; (2) The contents of DA in striatum had no change by injection of anti-NT serum into the substantia nigra. These results suggest that exogenous NT in substantia nigra can increase the content of DA from the striatum.

关 键 词：黑质区 神经降压素 多巴胺 纹状体 震颤麻痹 

分 类 号：R338.22[医药卫生—人体生理学] R742.502[医药卫生—基础医学]