纳米羟基磷灰石/丝素蛋白/聚己内酯复合超细纤维的制备及表征  

Preparation and characterization of ultrafine nano-hydroxyapatite/silk fibroin/poly(ε-caprolactone) composite fibers

作　　者：唐圣奎[1] 熊杰[1] 李妮[1] 谢军军[2] 肖红伟[1] 张红萍[1] 

机构地区：[1]浙江理工大学先进纺织材料与制备技术教育部重点实验室,杭州310018 [2]杭州师范大学临床医学院,杭州310036

出　　处：《复合材料学报》2010年第2期31-37,共7页Acta Materiae Compositae Sinica

基　　金：973计划前期研究课题(2008CB617506);长江学者和创新团队发展计划资助(IRT0654);先进纺织材料与制备技术教育部重点实验室开放基金资助项目(2006003)

摘　　要：通过静电纺丝法制备出纳米羟基磷灰石/丝素蛋白/聚己内酯复合超细纤维,利用扫描电镜、红外光谱仪、X射线衍射仪对纳米羟基磷灰石/丝素蛋白/聚己内酯复合超细纤维形貌和结构进行表征,并进行了拉伸测试。结果表明,随着超细纤维中羟基磷灰石含量的增加,纤维的直径逐渐降低,纤维中聚己内酯的结晶逐渐变差。相比于丝素蛋白/聚己内酯超细纤维,含有质量比为30%羟基磷灰石的复合超细纤维仍具有较好的力学性能。体外小鼠成纤维细胞(L929)培养表明,纳米羟基磷灰石/丝素蛋白/聚己内酯复合超细纤维对细胞没有毒性。Ultrafine nano-hydroxyapatite（nHA）/silk fibroin（SF）/poly（ε-caprolactone）（PCL） composite fibers were prepared via electrospinning.Scanning electron microscopy（SEM）,attenuated total reflectance-Fourier transform infrared spectroscopy（ATR-FTIR） and X-ray diffraction（XRD） were used to characterize the electrospun ultrafine nHA/SF/PCL composite fibers.The mechanical properties of fibers were also tested.The results show that the diameter of the fibers decreases and the crystallinity of PCL in the fibers becomes poor with increasing nHA content in the fibers.Compared with SF/PCL fibers,the mechanical properties of ultrafine nHA/SF/PCL composite fibers are still well when the nHA mass ratio is 30% in the fibers.In vitro mouse fibroblast（L929） cell culture indicates that the ultrafine nHA/SF/PCL composite fibers are non-toxicity.

关 键 词：纳米羟基磷灰石 丝素蛋白 聚己内酯 静电纺丝 复合超细纤维 

分 类 号：TB332[一般工业技术—材料科学与工程]