C-反应蛋白与左房内径相关性研究  

Investigation of Correlation between C-reactive Protein and Left Atrial Diameter

作　　者：王伟[1] 曹维锷[2] 曹佳齐[2] 任建英[2] 

机构地区：[1]上海市徐汇区中心医院急诊科,上海200031 [2]上海市徐汇区中心医院心内科,上海200031

出　　处：《中国临床医学》2010年第2期150-151,共2页Chinese Journal of Clinical Medicine

基　　金：上海市卫生局重点专科研究基金资助项目(编号:052Ⅱ028)

摘　　要：目的:通过对C-反应蛋白(CRP)与左房内径的相关性研究来探讨炎症在房颤发生及持续中的作用。方法:选择房颤患者66例,其中阵发性房颤26例,持续性房颤40例(含永久性房颤)。选择非房颤患者36例为对照组。采用免疫透射比浊法测定血清中的CRP含量,同时所有患者均进行超声心动图检查,测量左房内径(LAD)。结果:房颤组血清CRP(41.21±21.40mg·L-1)显著高于对照组(9.33±3.91mg·L-1),P<0.01;持续性房颤组血清CRP(48.51±22.88mg·L-1)显著高于阵发性房颤组(32.01±11.94mg·L-1),P<0.05。持续性房颤组左心房内径明显增大,与阵发性房颤组及对照组比较差异均有统计学意义(P<0.05)。阵发性房颤组左心房内径与对照组相比差异无统计学意义。持续性房颤组中血清CRP与左心房内径之间呈正相关(r=0.61,P<0.05)。结论:炎症是房颤发生和维持的重要基础。Objective：By investigating the correlation between C-reactive protein （CRP） and left atrial diameter to explore the role of inflammation in the occurrence and development of atrial fibrillation （AF）. Methods：Sixty-six cases of patients with atrial fibrillation,in which 26 patients with paroxysmal atrial fibrillation,40 patients with persistent atrial fibrillation （including permanent atrial fibrillation）,and 36 patients with non-atrial fibrillation were enrolled into the control group. Serum levels of CRP was measured with immunoturbidimetry assay,and all patients were carried out echocardiography to measure left atrial diameter （LAD）.Results：Serum level of CRP in the atrial fibrillation group （41.21±21.40 mg/L） was much higher than that in control group （9.33±3.91 mg/L） （P0.01）. The serum level of CRP in the persistent atrial fibrillation group （48.51±22.88 mg/L） was much higher than that in the paroxysmal atrial fibrillation group （32.01±11.94 mg/L）（P0.05）. LAD in the persistent atrial fibrillation group was significantly larger than that in the paroxysmal atrial fibrillation group and control group （P0.05）. But the difference of LAD between the paroxysmal atrial fibrillation group and the control group was not statistically significant. There was a positive correlation between CRP of persistent AF and LAD （r=0.61,P0.05）.Conclusions：Inflammation is an important basis for the occurrence and development of atrial fibrillation.

关 键 词：炎症 C-反应蛋白 房颤 

分 类 号：R541.75[医药卫生—心血管疾病]