2型糖尿病患者血清尿酸水平与肌酐清除率的关系  

Relationship of Serum Uric Acid Level with Creatinine Clearance Rate in Type 2 Diabetic Patients

作　　者：万静[1] 鹿斌[2] 杨叶虹[2] 杨志红[2] 胡仁明[2] 

机构地区：[1]上海市第八人民医院内分泌科,上海200235 [2]复旦大学附属华山医院内分泌科,上海200040

出　　处：《中国临床医学》2010年第2期214-215,共2页Chinese Journal of Clinical Medicine

基　　金：国家自然科学基金(编号:30900501);上海市科学技术委员会重大项目(编号:04dz19504);复旦大学青年基金(编号:08FQ37)

摘　　要：目的:初步探讨2型糖尿病患者血尿酸水平与肌酐清除率的关系。方法:选择华山医院住院的2型糖尿病患者163例,应用Cockcroft-Gault公式估计肌酐清除率,分析2型糖尿病患者血尿酸与肌酐清除率的关系。结果:(1)高尿酸血症组体质量指数、尿素氮、肌酐及尿酸水平均明显高于非高尿酸组(P<0.05),而糖化血红蛋白(HbA1c)及肌酐清除率均明显低于非高尿酸组(P<0.05);(2)血尿酸水平与肌酐清除率(相关系数:-0.161,P=0.043)及HbA1c(相关系数:-0.299,P<0.001)均显著负相关,HbA1c与肌酐清除率显著正相关(相关系数:0.184,P=0.032);(3)逐步Logistic回归分析显示,低HbA1c及高BMI为高尿酸血症的独立危险因素,肌酐清除率与血尿酸有负相关趋势。结论:2型糖尿病者血尿酸水平与HbA1c、肌酐清除率呈显著负相关,肌酐清除率的增高可能是2型糖尿病者血尿酸降低的原因之一。Objective：To explore the association of serum uric acid level with creatinine clearance rate in type 2 diabetic patients. Methods：One hundred sixty-three in-patients with type 2 diabetes in Huashan hospital were selected. Creatinine clearance rate was estimated by Cockcroft-Gault equation. The correlation analysis and logistic regression analysis were employed to test the relationship of serum uric acid,HbA1c and creatinine clearance rate. Results：（1） Body mass index,blood urea nitrogen,serum creatinine and serum uric acid in hyperuricemia subgroup were significantly higher than those in non-hyperuricemia subgroup. HbA1c and creatinine clearance rate in hyperuricemia subgroup were lower than those in non-hyperuricemia subgroup. （2） Seurm uric acid was negatively correlated with creatinine clearance rate （correlation coefficient：-0.161,P=0.043） and HbA1c（correlation coefficient：-0.299,P0.001）. HbA1c was correlated with creatinine clearance rate （correlation coefficient：0.184,P=0.032）. （3） Obesity and low HbA1c were risk factors of hyperuricemia by stepwise Logistic regression,and negative correlation tendency was also shown between serum uric acid and creatinine clearance rate. Conclusion：Seurm uric acid was negatively correlated with creatinine clearance rate and HbA1c in type 2 diabetic patients,and the increased creatinine clearance rate might contribute to the fall of serum uric acid level.

关 键 词：2型糖尿病血管 血尿酸 肌酐清除率 

分 类 号：R587.1[医药卫生—内分泌]