^(131)I治疗对Graves病眼病患者血清细胞因子水平的影响  

Changes of Serum IL-2 and IL-6 Levels in Patients with Graves' Ophthalmopathy before and after Treated with Iodine-131

作　　者：方文珠[1] 罗章伟[1] 林敏华[1] 廖书鸿[1] 陆进[1] 凌彩霞[1] 

机构地区：[1]右江民族医学院附属医院核医学科,广西百色533000

出　　处：《中国临床医学》2010年第2期264-266,共3页Chinese Journal of Clinical Medicine

基　　金：广西壮族自治区卫生厅科研基金项目(编号:z2007358)

摘　　要：目的:探讨131I治疗后Graves眼病(GO)患者血清细胞因子水平的变化。方法:用放射免疫分析法(RIA)检测120例Graves病眼病(GO)患者和50例Graves病无眼病患者(NGO)治疗前和治疗后90d血清白介素-2(IL-2)和白介素-6(IL-6)水平,分析其与血清甲状腺激素水平的相关性分析及治疗前后IL-2/IL-6比值。选30例健康者作为健康对照组。结果:治疗前GO患者较健康对照组IL-2水平明显低于健康对照组,IL-6水平明显较健康对照组高(P<0.01);经131I治疗后,GO改善者IL-2水平显著升高,IL-6水平显著降低(P<0.01);GO无变化者IL-2水平、IL-6水平无明显改变;GO加重者IL-2水平比治疗前进一步降低、IL-6水平进一步升高。结论:131I治疗能有效抑制GO患者自身免疫。Objective：To study the changes of serum cytokine levels in patients with Graves＇ophthalmopathy （GO） before and after treated with iodine-131.Methods：Using the method radoimmunoassay,the serum levels of interleukin-2 （IL-2） and interleukin-6 （IL-6）of Graves＇ophthalmopathy 120 patients before and after treated with iodine-131 and 30 control subjects were measured. Results：In GO patients of pre-treatment,the IL-2 levels were significantly lower,while IL-6 levels were significantly higher than those in the control group （P0.01）;After iodine-131 treatment,GO improvement in patients with elevated IL-2 levels,IL-6 levels decreased,while in GO non-changes patients,the IL-2 and the IL-6 levels didn＇t change obviously（P0.05）,GO aggravates the patient IL-2 level goes forward one step compared to before the treatment to reduce,The IL-6 level further elevates. Conclusions：Successful iodine-131 therapy would effectively suppress the to-immune status in Graves＇ophthalmopathy patients.

关 键 词：GRAVES眼病 白介素-2 白介素-6 131碘治疗 

分 类 号：R581.1[医药卫生—内分泌]