检测核不均一核糖核蛋白A2/B1在胸水细胞学鉴别诊断中的意义  

Detection of hnRNPA2/B1 in Differential Diagnosis of Pleural Effusion Cytology

作　　者：石园[1] 陈颖[2] 侯英勇[1] 胡沁[1] 周杨[1] 孙路得[1] 谢红仙[1] 宿杰阿克苏[1] 谭云山[1] 

机构地区：[1]复旦大学附属中山医院病理科,上海200032 [2]复旦大学附属肿瘤医院病理科,上海200032

出　　处：《中国临床医学》2010年第2期282-283,共2页Chinese Journal of Clinical Medicine

基　　金：复旦大学青年科学基金(编号:154)

摘　　要：目的:观察核不均一核糖核蛋白A2/B1(hnRNPA2/B1)在胸水转移性肺腺癌细胞和间皮细胞中的表达,评价其用于两者鉴别诊断的价值。方法:采用细胞块技术对100例胸水进行免疫组织化学检测,观察hnRNPA2/B1在肺腺癌细胞和间皮细胞中的表达。结果:hnRNPA2/B1标记肺腺癌细胞的敏感度为100%,特异度为70%。结论:检测hnRNPA2/B1对鉴别胸水肺腺癌细胞和间皮细胞很有帮助。Objective：To evaluate the value of heterogeneous nuclear ribonucleoprotein （hnRNPA2/B1） in identifying the adenocarcinoma cells in pleural effusions.Methods：One hundred effusion specimen were assessed by immunohistochemical analysis in cell blocks.Results：The sensitivity rate of hnRNPA2/B1 was 100% and the specificity rate was 70%.Conclusions：Detection of hnRNPA2/B1 is an accessory method for differentiation between metastasis cancer and mesothelial cells.

关 键 词：核不均一核糖核蛋白A2/B1 细胞块 胸水 免疫组织化学 

分 类 号：R446.9[医药卫生—诊断学]