强酸性阳离子交换树脂催化合成对羟基苯乙酸甲酯  

Synthesis of methyl 4-hydroxyphenylacetate by strong acidic cation exchange resin

作　　者：束影[1] 

机构地区：[1]扬州工业职业技术学院化学工程系,江苏扬州225127

出　　处：《应用化工》2010年第4期562-564,共3页Applied Chemical Industry

摘　　要：以对羟基苯乙酸和甲醇为原料，强酸性阳离子交换树脂为催化剂，研究了催化剂种类、反应时间、反应温度、原料配比、催化剂用量及催化剂重复使用次数对反应的影响，确定了反应的最佳工艺条件为：反应温度为65—70℃，反应时间为4h，醇酸摩尔比为4：1，催化剂用量为反应物料总质量的1．5％，酯化收率为85．O％，产品纯度可达到98．5％。使用的催化剂732型强酸性阳离子交换树脂不经处理可重复使用10次以上，显示了较好的稳定性，同时具有催化活性好、价格低廉、不腐蚀设备、无环境污染等优点。Methyl 4-hydroxyphenylacetate was synthesized from p-hydroxyphenylacetic acid and methyl al- cohol by direct esterification using strong acidic cation exchange＇resin. The effects of reaction tempera- ture, reaction time, materials ratio, the content and species of catalyst on the synthesis were studied. The proper synthesis conditions were determined as follows：reaction temperature is 65 - 70 ℃, reaction time is 4 h, the amount of catalyst for the reaction is 1.5% of the total mass of material, the yield of esterification is 85 %, purity can reach 98.5 %. After ten experiments, activity and capacity of the 732 strong acidic cat- ion exchange resin remained. Experimental results showed that the strong acidic cation exchange resin has many advantages, such as high activity, low cost, non-corrosive to equipment and pollution-free to environment.

关 键 词：对羟基苯乙酸 对羟基苯乙酸甲酯 催化合成 强酸性阳离子交换树脂 

分 类 号：TQ225.24[化学工程—有机化工]