壳聚糖在肝细胞微载体材料中的应用  

The characteristics of chitosan and its application in microcarrier of liver cell

作　　者：杨波[1] 刘宝林[1] 周燕[1] 王欣[1] 

机构地区：[1]上海理工大学医疗器械与食品学院,上海200093

出　　处：《应用化工》2010年第4期590-591,601,共3页Applied Chemical Industry

基　　金：国家自然科学基金(50776060);教育部新世纪优秀人才计划资助(07-0559);上海市东方学者计划资助

摘　　要：壳聚糖是微载体的天然材料,由于其具有无毒性、无刺激性、良好的生物相容性、生物可溶解性,以及高的电荷密度,因而被作为一种新型的天然生物材料得到广泛应用;而微载体是目前较常用而有效的动物细胞大规模培养的载体,微载体培养技术已经成为动物细胞工程的基础和细胞学研究的主要技术和热点之一。文章就微载体及其在肝细胞培养中的研究进展进行综述,并介绍了壳聚糖的结构和性质,以及壳聚糖微载体在肝细胞培养中的应用。Chitosan has non-toxic, non-irritant, good biocompatibility, biodegradability and high charge density that make chitosan suitable for wide use as a new natural biomaterial. Microcarrier is more commonly used and effective large scale animal cell culture carrier. Mierocarrier culture technology has be- come one of the main technical and hot spots on basis of animal cell engineering and cellular research. The microcarrier and the research progress of its application in the liver cell culture were reviewed. The structure and properties of chitosan, as well as liver cells in the preparation of chitoson applications, were also described.

关 键 词：微载体 肝细胞 壳聚糖 

分 类 号：TQ917[化学工程]