肿瘤坏死因子α与心力衰竭及心肌细胞凋亡的研究进展  

Tumor Necrosis Factor-α and Apoptosis of Cardiomyocytes in Chronic Heart Failure

作　　者：段纬喆[1] 赵延恕[1] 

机构地区：[1]中南大学湘雅二医院心内科,长沙410000

出　　处：《医学综述》2010年第9期1284-1287,共4页Medical Recapitulate

基　　金：湖南省卫生厅科研基金(B2008-013)

摘　　要：心力衰竭是大多数心脏疾病的严重或终末阶段。近年研究表明,心力衰竭过程中存在细胞凋亡的现象。心肌细胞的凋亡在心力衰竭的发生发展机制中起重要作用。肿瘤坏死因子α(TNF-α)通过外部凋亡通路即死亡受体通路和内部凋亡通路即线粒体通路介导心肌细胞的凋亡,同时TNF-α又可激活核因子κB、AKT抑制心肌细胞的凋亡,说明TNF-α介导的心肌细胞凋亡具有双向效应,此与细胞转导通路有关。Heart failure is the severe or end-stage in most heart disease.Recent studies have demonstrated that cardiac myocytes undergoing apoptosis in heart failure,and apoptosis played an important role in the pathogenesis of heart failure,tumor necrosis factor-αinduced cardiomyocytes apoptosis through external pathway that was death recptor pathway and internal pathway that was mitochondrial pathway,the same time,it inhibition cardiomyocytes apoptosis through activation the nuclear factorκB and AKT,which means tumor necrosis factor-αinduced cardiomyocytes apoptosis with a two way.

关 键 词：肿瘤坏死因子Α 凋亡 心肌细胞 心力衰竭 

分 类 号：R541.6[医药卫生—心血管疾病]