四黄膏基质的选择与质量研究  

Bases Selecting and Quality Analysis of Sihuang Gao

作　　者：张萱[1] 刘起华[1] 文谨[1] 王菲[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053

出　　处：《中国中医药信息杂志》2010年第5期41-42,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：中国中医科学院广安门医院资助课题(2003s67)

摘　　要：目的选择制备四黄膏的适宜基质并探讨其质量控制方法。方法采用黄芩、黄柏、大黄、黄连4种药材的超微细粉制备不同基质配方的四黄膏,并考察不同配方的抑菌作用,同时进行初步稳定性试验研究。对最佳基质配方四黄膏进行薄层色谱法鉴别,观察其局部外用后对皮肤的刺激性作用。结果水溶性型基质的四黄膏抑菌作用最强,最稳定,且无刺激性,制剂处方中主药均能被检测出。结论该制剂质量可控,可为临床提供四黄膏的改进配方。Objective To select the optimum bases for Sihuang Gao and study the method for quality control. Method Ultra-fine powders of Radix Scutellariae, Cortex Phellodendri, Radix et Rhizoma Rhei and Rhizoma Coptidis were used to prepare Sihuang Gao with different formulations, the bacteriostatic action of which were compared and stability were inspected. The best prescription was identified by TLC, and the skin irritation was observed. Result Sihuang Gao made of water-soluble base had a strong antibacterial activity and stable quality, and it was proved no irritation, the contents of active component could be detected by TLC. Conclusion The quality was controllable, and the improvement prescription can be used in the clinic.

关 键 词：四黄膏 基质 质量研究 

分 类 号：R283.5[医药卫生—中药学]