昂丹司琼预防腹腔镜胆囊切除术后恶心呕吐的临床观察  

The investigation of the prophylactic effect of ondansetron on postoperative vomiting after laparoscopic cholecystectomy

作　　者：先德飞[1] 笪庆[1] 郑膨[1] 林云才[1] 张乐[1] 

机构地区：[1]武警四川总队医院麻醉科,四川乐山614000

出　　处：《四川医学》2010年第4期494-496,共3页Sichuan Medical Journal

摘　　要：目的观察昂丹司琼预防腹腔镜胆囊切除手术(LC)恶心呕吐(PONV)方案的临床疗效。方法将200例行LC的患者随机分5组:Ⅰ组(对照组):生理盐水10ml;Ⅱ组:昂丹司琼4mg;Ⅲ组:昂丹司琼4mg+地塞米松10mg;Ⅳ组:昂丹司琼8mg;Ⅴ组:昂丹司琼4mg+胆囊切除后昂丹司琼4mg,记录术后6、12、24h患者的PONV程度。结果与Ⅰ组相比,其余4组24h内PONV的发生率明显下降(P<0.01);Ⅲ组的发生率低于Ⅱ、Ⅳ、Ⅴ组(P<0.05);Ⅱ组与Ⅳ、Ⅴ组之间比较,差异无统计学意义。结论昂丹司琼联合地塞米松方案预防PONV疗效好,不良反应少,费用低。Objective To investigate the prophylactic effect of ondansetron on postoperative vomitting after laparoscopic cholecystectomy.Methods Two hudered patients were divided into 5groups randomly,respectively treated with saline 10ml（Ⅰgroup）;ondansearon 4mg（Ⅱgroup）;ondansetron 4mg＋dexamethasone 10mg（Ⅲ group）;ondansetron 8mg（Ⅳ group）,ondansetron 4mg（befor anesthesia induction）＋ondansetron 4mg（after LC）（V group）.Make a different record about the degree of PONV on patients after operation 6、12、24h.Results The incidence of PONV on the other 4groups decresase obviously within 24hs,comparing with Ⅰ group,and the incidence of Ⅲ group is lower than Ⅱ,Ⅳand Ⅴ group（P0.05）.In addition,there is no comparision and significant difference among Ⅱ group,Ⅳ group and Ⅴ group.Conclusion The prophylactic effect of ondansetron＋dexamethasone on PONV is better for less advers reactions and expense.

关 键 词：腹腔镜胆囊切除手术 术后恶心呕吐 昂丹司琼 

分 类 号：R614[医药卫生—麻醉学]