除草剂氰氟草酯的合成  

Synthesis of Herbicide Cyhalofop-butyl

作　　者：张继旭[1] 郑鹛 王剑峰[1] 罗书平[1] 许丹倩[1] 

机构地区：[1]浙江工业大学绿色化学合成技术国家重点实验室培育基地,杭州310014 [2]杭州华东医药集团生物工程研究所有限公司,杭州310015

出　　处：《农药》2010年第5期329-331,337,共4页Agrochemicals

摘　　要：对苯二酚和3,4-二氟苯腈通过选择性单醚化反应合成中间体4-(4-氰基-2-氟苯氧基)苯酚,再与(S)-2-(4-甲基苯磺酰氧基)丙酸丁酯反应得到氰氟草酯,所得产物经过MS和1HNMR确证。在较佳的反应条件下,反应总收率为82.2%,氰氟草酯的化学纯度为98.6%,ee值为98.0%。Herbicide cyhalofop-butyl was synthesized from the SN2 reaction of （S）-butyl 2-（4-toluenesulfonyloxy） lactate with the intermediate 4-（4-cyano-2-fluorophenoxy）phenol, which was obtained by the selective etherification of hydroquinone with 3,4-difluorobenzonitrile. The structure of the target compound was confirmed by MS and ^1H NMR. Under the optimal conditions, the chemical purity and the optical purity of the product were up to 98.6 and 98.0% ee, respectively, with the total yield being 82.2%.

关 键 词：氰氟草酯 合成 3 4-二氟苯腈 对苯二酚 

分 类 号：TQ457.2[化学工程—农药化工]