结节性痒疹皮损中P物质受体的表达  

Immunohistochemical Study on the Distribution of SP Receptor in Lesion of Prurigo Nodularis

作　　者：胡小平[1] 谢谦[1] 吴波[1] 马刚[1] 钟绮丽[1] 王万卷[2] 

机构地区：[1]北京大学深圳医院皮肤科,广东深圳518035 [2]西安交通大学第二医院皮肤科

出　　处：《南华大学学报（医学版）》2010年第1期115-117,共3页Journal of Nanhua University(Medical Edition)

摘　　要：目的探讨神经肽P物质受体(SPR;NK-1R)在结节性痒疹皮损中的表达与分布。方法采用SABC免疫组化法对30例结节性痒疹患者的皮损、非皮损区以及15例正常人皮肤中SPR进行染色观察,应用图像分析仪做半定量分析测定,并进行统计学处理。结果结节性痒疹皮损中SPR的免疫反应性明显增强,与正常对照及未受累皮肤比较差异均有显著性;SPR的反应性在非皮损和正常对照比较中差异无显著性。结论SPR的过度表达在结节性痒疹的发病中起一定作用。Objective To investigate the distribution and expression of substance P receptor（SPR;Neurokinin-1R：NK-1R） in prurigo nodularis（PN）,then to study the role of SPR in the pathogenesis in PN.Methods The staining of SPR was studied in skin biopsies from lesional skin and uninvolved skin in 30 cases with PN,and in 15 normal controls.The immunohistochemistry technique was employed to measure the antibodies against SPR,then semiquantitive analysis were made by image analytic instrument,and stastical analysis were also made. Results An increase in reactivity against SPR antibody was seen in patients with PN in the leisional skin,compared with that in control and uninvolved skin.The difference of positive expression of SPR has no stastical significance. Conclusion These findings support the concept of neuronal or neuropeptide involvement in prurigo nodularis,and suggest that SPR may have a role in the pathogenesis of the disease.

关 键 词：结节性痒疹 P物质受体 免疫组化 

分 类 号：R75[医药卫生—皮肤病学与性病学]