高龄老年患者血清胰高血糖素样肽-1的动态变化及其临床意义  

Dynamic changes of serum GLP-1 and clinical significance in elderly patients

作　　者：牛宪萍[1] 邵莉[1] 陈巍[1] 滕丽莉[1] 张华[1] 

机构地区：[1]同济大学附属东方医院老年医学科,上海200120

出　　处：《疑难病杂志》2010年第5期340-342,共3页Chinese Journal of Difficult and Complicated Cases

基　　金：上海市浦东新区科技发展创新基金资助(No.PKJ2008-34)

摘　　要：目的检测高龄老年患者血清胰高血糖素样肽-1(GLP-1)的动态变化及临床意义。方法96例80岁以上患各种慢性疾病的老年患者作为观察组,32例健康体检者作为健康对照组,采用酶联免疫吸附试验检测空腹及餐后2 h血清GLP-1浓度,进行比较分析。结果健康对照组空腹血清GLP-1平均浓度为(0.973±0.385)μg/L,餐后2 h为(7.406±2.418)μg/L;观察组空腹血清GLP-1平均浓度为(0.885±0.461)μg/L,餐后2 h为(4.103±0.613)μg/L。2组餐后2 h血清GLP-1均高于空腹血清GLP-1(P<0.01);观察组空腹血清GLP-1与健康对照组比较差异无统计学意义(P>0.05),而餐后2 h血清GLP-1则显著低于健康对照组(P<0.05)。结论高龄老年患者餐后血清GLP-1浓度明显升高,而2型糖尿病老年患者血清GLP-1浓度无明显升高。Objective To explore the dynamic changes of serum glucagon like peptide-1（GLP-1） in the elderly patients,and to analyze the clinical significance among the various diseases in the elderly.Methods The serum concentration of GLP-1 was examined using ABC-ELISA at empty and 2h postprandial in the 96 cases of elderly patients,which had various chronic diseases,and 32 cases of the healthy persons as controls.Data were analyzed with unpaired t test.Results The average concentration of serum GLP-1 in the healthy controls was（0.973±0.385）μg/ L at empty,and（7.406±2.418）μg/L 2 h after meal,while the value in elderly patients was（0.885±0.461）μg/L and（4.103±0.613）μg/L respectively.The average concentration was higher in 2 h after meal than empty in both two groups（P0.01）.There were no significant differences of the serum levels of GLP-1 among the different disease groups（P0.05）.There was no statistical difference in empty between elderly patients group and control group（P0.05）,while it was lower in 2h after meal in elderly group（P0.05）.Conclusion The postprandial concentration of serum GLP-1 elevated in the elderly,but not in the elderly with type 2 diabetes.

关 键 词：胰高血糖素样肽-1 糖尿病 2型 酶联免疫吸附试验 老年人 

分 类 号：R446.6[医药卫生—诊断学]