H_(22)小鼠肝癌细胞接种数与实验性肺转移的相关性  被引量:2

Research Correlation Cell Number of Mouse H_(22) Liver Carcinoma with Occurrence of the Experimental Pulmonary Metastasis

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作  者:吕祥[1] 李柏[1] 凌昌全[1] 

机构地区:[1]第二军医大学附属长海医院,上海200433

出  处:《浙江中医药大学学报》2010年第2期169-171,共3页Journal of Zhejiang Chinese Medical University

摘  要:目的:探讨H22小鼠肝癌细胞接种数与实验性肺转移的相关性。方法:昆明种小鼠尾静脉注射不同数量(1×107、7.5×106、5×106、2.5×106、1×106)H22细胞制作实验性肺转移模型,肉眼及镜下观察肺内肿瘤的有无、大小、转移程度及分布情况,血清ICAM-1、IL-2蛋白的表达情况。结果:接种1×107细胞浓度组小鼠肺转移率、恶化程度及血清中ICAM-1蛋白表达的量均高于其他接种组(P<0.01),IL-2蛋白表达低于其他接种组(P<0.01),其中部分小鼠有脑转移。结论:小鼠实验性肺转移的发生率、转移程度及血清中ICAM-1、IL-2蛋白的表达量与细胞接种数变化密切相关。[Objective]To study correlation cell number of mouse H22 liver carcinoma with occurrence of the experimental pulmonary metastasis.[Method]The Kunming mouse experimental pulmonary metastatic model of different H22 liver carcinoma cell numbers was established by injecting tail vein;distribution,size and grade of metastatic nodes were observed by naked eye and microscope,expressing of ICAM-1 and IL-2 in blood serum of mouse was detected.[Result]Rate and grade of pulmonary metastasis and expressing of ICAM-1 in blood serum were higher for mouse of injecting1×10^7cell number than other groups,and lower for expressing of IL-2 in blood serum obviously,some had brain metastases among these mice.[Conclusion]The rate and grade of mice experimental pulmonary metastasis and expressing of ICAM-1,IL-2 are correlated with cell number.

关 键 词:肝癌 ICAM-1 IL-2 实验性肺转移 

分 类 号:R599.9[医药卫生—内科学]

 

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