相对剂量反应评价肺炎及腹泻患儿的维生素A状况  

Assessment of Vitamin A Status in Children with Pneumonia or Diarrhea Using the Relative Dose Response Procedure

作　　者：谈藏文[1] 吴光驰[1] 周新宇[1] 潘红[1] 孙吉萍[1] 聂明[1] 王树山[1] 邓莉[1] 

机构地区：[1]首都儿科研究所儿童营养研究室,北京100020

出　　处：《中华儿童保健杂志》1998年第3期173-175,共3页

摘　　要：目的 评价肺炎、腹泻患儿维生素A(VA)状况.方法 以相对剂量反应(RDR)和血清VA测定法研究60例肺炎,85例腹泻患儿的VA状况,并对这两种方法进行比较.RDR≥20%为亚临床VA缺乏(PVAD)状态的诊断标准.结果 43.3%的肺炎患儿和61.2%的腹泻患儿体内处于PVAD.肺炎和腹泻患儿的RDR值和血清VA值均呈负相关(r=-0.618,r=-0.476).诊断肺炎和腹泻患儿 PVAD时两种方法的诊断符合率分别为75.0%和71.8%.当血清VA≤ 0.35μmol/L,>1.40μmol/L时两种方法的符合率最高,血清VA在0.70～1.01μmol/L时两种方法的符合率最低.当血清VA值在0.70～1.01μmol/L,血清VA 测定法的评价结果并非完全可靠,进行个体判断需谨慎,此时RDR较血清VA测定法更为敏感可靠.结论 RDR不仅能用于评价健康人群,也可用于评价肺炎和腹泻患者体内VA状况;PVAD是肺炎和腹泻患儿值得注意的营养问题.ve To assess of uitamin A (VA) status in children with pneumonia or diar-rhea. Methods Relative dose response(RDR) and serum VA determination were performed on 60 pneumonia cases, 85 diarrhea cases, furthermore did comparison of methodology. The diagnostic criterion of preclinical vitamin A deficiency (PVAD) is RDR≥20%. Results The incidences of PVAD in children with pneumonia or diarrhea were 43. 3% ,61. 2% respectively. A linear negative correlation between RDR and serum VA level in suffers with pneumonia or diarrhea( r=- 0.618,r = -0.476). In define as PVAD of cases with pneumonia or diarrhea, correspondence rate of the two methods were 75.0% ,71. 8% respectively. When serum VA levels were≤0. 35/μmol/L, >1. 40μmol/L,the correspondence rate were the highest, 0. 70 - 1.01μmol/L, the correspondence rate were the lowest. The RDR is a more reliable and sensitive indicator of total body VA status than serum VA determination, particularly serum VA levels are 0.71- 1. 01μmol/L. Conclusion PVAD is an important nutrient problem in suffers with pneumonia or diarrhea. RDR not only have applicability in healthy people, but also in suffers with pneumonia or diarrhea.

关 键 词：相对剂量反应 维生素A 肺炎 腹泻 儿童 

分 类 号：R725.631[医药卫生—儿科] R512.5[医药卫生—临床医学]