转录因子——新型抗肿瘤药物作用靶点  

Transcription factors as new targets for cancer therapy

作　　者：刘楠[1] 陈依军[1] 

机构地区：[1]中国药科大学化学生物学研究室,南京210009

出　　处：《中国药科大学学报》2010年第2期97-103,共7页Journal of China Pharmaceutical University

摘　　要：真核生物基因的调控机制是当前分子生物学较为活跃的研究领域之一,而转录水平的调控是基因发挥功能的一个复杂过程。转录因子因其存在的广泛性和调控靶基因的多样性,与肿瘤细胞的生长、增殖、凋亡、浸润转移及血管生成等各个环节密切相关。随着对转录因子及其作用机制的深入研究,针对转录因子活化与抑制从不同环节寻找药物用于靶向治疗和预防与转录因子调控相关的肿瘤疾病,已成为当今新的研究热点,有望成为研究新型抗肿瘤药物作用机制的有效途径。Mechanism studies in the gene regulation in the eukaryotic cells is one of the momentous areas in molecular biology.Regulation at transcription level is a complex progress with multiple steps with the presence of the gene functions.There exist ubiquitous occurrence of transcription factors in mammalian tissues and biodiversity in the factors.These transcription factors are found to relate closely to various carcinogeneses,including cell proliferation,apoptosis,invasion and angiogenesis.Understanding of transcription factors and their action mechanisms,through the activation and inhibition of transcription factors, would potentially lead to the discovery of new entities in the targeting treatment and prevention of the cancer diseases.

关 键 词：转录因子 抗肿瘤 核转录因子 信号转导和转录激活因子 活化T细胞核因子 

分 类 号：R96[医药卫生—药理学]